HLA-class II antigen expression in human heart-lung allografts

Samuel A. Yousem, Joseph M. Curley, James Dauber, Irvin Paradis, Hanna Rabinowich, Adriana Zeevi, Rene Duquesnoy, Robert Dowling, Marco Zenati, Robert Hardesty, Bartley P. Griffith

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47 Scopus citations

Abstract

Long-term survival in heart-lung transplantation has ben hindered by the development of bronchiolitis obliterans (OB), which is believed to be a manifestation of chronic rejection of the lung. Since HLA-class II antigens are involved in the rejection response, the distribution of the class II products HLA-DR, HLA-DQ, and HLA-DP were studied in normal lung, and in transplanted lung with and without OB, utilizing frozen- section immunohistochemical techniques. All three allelic products are usually expressed on the epithelial, endothelial, and mesenchymal components of the lung. Sequential transbronchial biopsies from 4 recipients before and concurrent with the diagnosis of OB were stained with serial dilutions of monoclonal antibodies to assess the level of expression of the above class II products. Increased levels of HLA-DR and HLA-DP antigens may be seen on the bronchial and bronchiolar epithelium during OB, but the changes are subtle and complicated by many other variables. Additional studies are needed to confirm these preliminary results.

Original languageEnglish (US)
Pages (from-to)991-995
Number of pages5
JournalTransplantation
Volume49
Issue number5
DOIs
StatePublished - May 1990

All Science Journal Classification (ASJC) codes

  • Transplantation

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    Yousem, S. A., Curley, J. M., Dauber, J., Paradis, I., Rabinowich, H., Zeevi, A., Duquesnoy, R., Dowling, R., Zenati, M., Hardesty, R., & Griffith, B. P. (1990). HLA-class II antigen expression in human heart-lung allografts. Transplantation, 49(5), 991-995. https://doi.org/10.1097/00007890-199005000-00030