HLA class II glycoprotein expression by monocytes from HIV-infected individuals: Differences in response to interferon-gamma

B. S. Zwilling, R. Darrow, M. McPeek, H. Laufman, D. Pearl

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The expression of HLA class II glycoproteins by monocytes from HIV-infected individuals was evaluated. We found no differences in HLA-DR, HLA-DQ, or HLA-DP expression by freshly isolated monocytes from patients with clinical AIDS, HIV-infected patients without AIDS or from uninfected individuals. However, monocytes from HIV-infected individuals without AIDS responded better to stimulation with recombinant human interferon-gamma (IFN-γ) than did monocytes from patients with clinical AIDS or from uninfected individuals. The response to IFN-γ stimulation by monocytes from patients with clincal AIDS was different. Thus, the largest increases in the percentage of cells expressing HLA-DR was associated with the smallest changes in the fluorescence intensity of the population that is observed following stimulation of monocytes from other patient populations.

Original languageEnglish (US)
Pages (from-to)553-558
Number of pages6
JournalClinical and Experimental Immunology
Volume82
Issue number3
DOIs
StatePublished - 1990

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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