HLA class II glycoprotein expression by monocytes from HIV-infected individuals: Differences in response to interferon-gamma

B. S. Zwilling, R. Darrow, M. McPeek, H. Laufman, D. Pearl

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The expression of HLA class II glycoproteins by monocytes from HIV-infected individuals was evaluated. We found no differences in HLA-DR, HLA-DQ, or HLA-DP expression by freshly isolated monocytes from patients with clinical AIDS, HIV-infected patients without AIDS or from uninfected individuals. However, monocytes from HIV-infected individuals without AIDS responded better to stimulation with recombinant human interferon-gamma (IFN-γ) than did monocytes from patients with clinical AIDS or from uninfected individuals. The response to IFN-γ stimulation by monocytes from patients with clincal AIDS was different. Thus, the largest increases in the percentage of cells expressing HLA-DR was associated with the smallest changes in the fluorescence intensity of the population that is observed following stimulation of monocytes from other patient populations.

Original languageEnglish (US)
Pages (from-to)553-558
Number of pages6
JournalClinical and Experimental Immunology
Volume82
Issue number3
StatePublished - Jan 1 1990

Fingerprint

Individuality
Interferon-gamma
Monocytes
Glycoproteins
HIV
Acquired Immunodeficiency Syndrome
HLA-DR Antigens
HLA-DP Antigens
HLA-DQ Antigens
Population
Fluorescence

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

@article{15612ffe04d549ab9b739d572ddb7ed9,
title = "HLA class II glycoprotein expression by monocytes from HIV-infected individuals: Differences in response to interferon-gamma",
abstract = "The expression of HLA class II glycoproteins by monocytes from HIV-infected individuals was evaluated. We found no differences in HLA-DR, HLA-DQ, or HLA-DP expression by freshly isolated monocytes from patients with clinical AIDS, HIV-infected patients without AIDS or from uninfected individuals. However, monocytes from HIV-infected individuals without AIDS responded better to stimulation with recombinant human interferon-gamma (IFN-γ) than did monocytes from patients with clinical AIDS or from uninfected individuals. The response to IFN-γ stimulation by monocytes from patients with clincal AIDS was different. Thus, the largest increases in the percentage of cells expressing HLA-DR was associated with the smallest changes in the fluorescence intensity of the population that is observed following stimulation of monocytes from other patient populations.",
author = "Zwilling, {B. S.} and R. Darrow and M. McPeek and H. Laufman and D. Pearl",
year = "1990",
month = "1",
day = "1",
language = "English (US)",
volume = "82",
pages = "553--558",
journal = "Clinical and Experimental Immunology",
issn = "0009-9104",
publisher = "Wiley-Blackwell",
number = "3",

}

HLA class II glycoprotein expression by monocytes from HIV-infected individuals : Differences in response to interferon-gamma. / Zwilling, B. S.; Darrow, R.; McPeek, M.; Laufman, H.; Pearl, D.

In: Clinical and Experimental Immunology, Vol. 82, No. 3, 01.01.1990, p. 553-558.

Research output: Contribution to journalArticle

TY - JOUR

T1 - HLA class II glycoprotein expression by monocytes from HIV-infected individuals

T2 - Differences in response to interferon-gamma

AU - Zwilling, B. S.

AU - Darrow, R.

AU - McPeek, M.

AU - Laufman, H.

AU - Pearl, D.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The expression of HLA class II glycoproteins by monocytes from HIV-infected individuals was evaluated. We found no differences in HLA-DR, HLA-DQ, or HLA-DP expression by freshly isolated monocytes from patients with clinical AIDS, HIV-infected patients without AIDS or from uninfected individuals. However, monocytes from HIV-infected individuals without AIDS responded better to stimulation with recombinant human interferon-gamma (IFN-γ) than did monocytes from patients with clinical AIDS or from uninfected individuals. The response to IFN-γ stimulation by monocytes from patients with clincal AIDS was different. Thus, the largest increases in the percentage of cells expressing HLA-DR was associated with the smallest changes in the fluorescence intensity of the population that is observed following stimulation of monocytes from other patient populations.

AB - The expression of HLA class II glycoproteins by monocytes from HIV-infected individuals was evaluated. We found no differences in HLA-DR, HLA-DQ, or HLA-DP expression by freshly isolated monocytes from patients with clinical AIDS, HIV-infected patients without AIDS or from uninfected individuals. However, monocytes from HIV-infected individuals without AIDS responded better to stimulation with recombinant human interferon-gamma (IFN-γ) than did monocytes from patients with clinical AIDS or from uninfected individuals. The response to IFN-γ stimulation by monocytes from patients with clincal AIDS was different. Thus, the largest increases in the percentage of cells expressing HLA-DR was associated with the smallest changes in the fluorescence intensity of the population that is observed following stimulation of monocytes from other patient populations.

UR - http://www.scopus.com/inward/record.url?scp=0025222503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025222503&partnerID=8YFLogxK

M3 - Article

C2 - 2124960

AN - SCOPUS:0025222503

VL - 82

SP - 553

EP - 558

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - 3

ER -