Homeostatic competition between phasic and tonic inhibition

Xia Wu, Lanting Huang, Zheng Wu, Ce Zhang, Dongyun Jiang, Yuting Bai, Yun Wang, Gong Chen

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Synaptic and extrasynaptic GABAA receptors mediate phasic and tonic inhibition, respectively. Results: Overexpression of extrasynaptic GABAA receptors decreases synaptic GABAergic transmission. Conclusion: Synaptic and extrasynaptic GABAA receptors may have intrinsic competition in single individual neurons. Significance: Phasic and tonic inhibition interacts to maintain homeostasis of total inhibition.

Original languageEnglish (US)
Pages (from-to)25053-25065
Number of pages13
JournalJournal of Biological Chemistry
Volume288
Issue number35
DOIs
StatePublished - Aug 30 2013

Fingerprint

GABA-A Receptors
Synaptic Transmission
Neurons
Homeostasis

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Wu, Xia ; Huang, Lanting ; Wu, Zheng ; Zhang, Ce ; Jiang, Dongyun ; Bai, Yuting ; Wang, Yun ; Chen, Gong. / Homeostatic competition between phasic and tonic inhibition. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 35. pp. 25053-25065.
@article{34282823cbef4e15a42d4f17c6566b8e,
title = "Homeostatic competition between phasic and tonic inhibition",
abstract = "Background: Synaptic and extrasynaptic GABAA receptors mediate phasic and tonic inhibition, respectively. Results: Overexpression of extrasynaptic GABAA receptors decreases synaptic GABAergic transmission. Conclusion: Synaptic and extrasynaptic GABAA receptors may have intrinsic competition in single individual neurons. Significance: Phasic and tonic inhibition interacts to maintain homeostasis of total inhibition.",
author = "Xia Wu and Lanting Huang and Zheng Wu and Ce Zhang and Dongyun Jiang and Yuting Bai and Yun Wang and Gong Chen",
year = "2013",
month = "8",
day = "30",
doi = "10.1074/jbc.M113.491464",
language = "English (US)",
volume = "288",
pages = "25053--25065",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "35",

}

Homeostatic competition between phasic and tonic inhibition. / Wu, Xia; Huang, Lanting; Wu, Zheng; Zhang, Ce; Jiang, Dongyun; Bai, Yuting; Wang, Yun; Chen, Gong.

In: Journal of Biological Chemistry, Vol. 288, No. 35, 30.08.2013, p. 25053-25065.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Homeostatic competition between phasic and tonic inhibition

AU - Wu, Xia

AU - Huang, Lanting

AU - Wu, Zheng

AU - Zhang, Ce

AU - Jiang, Dongyun

AU - Bai, Yuting

AU - Wang, Yun

AU - Chen, Gong

PY - 2013/8/30

Y1 - 2013/8/30

N2 - Background: Synaptic and extrasynaptic GABAA receptors mediate phasic and tonic inhibition, respectively. Results: Overexpression of extrasynaptic GABAA receptors decreases synaptic GABAergic transmission. Conclusion: Synaptic and extrasynaptic GABAA receptors may have intrinsic competition in single individual neurons. Significance: Phasic and tonic inhibition interacts to maintain homeostasis of total inhibition.

AB - Background: Synaptic and extrasynaptic GABAA receptors mediate phasic and tonic inhibition, respectively. Results: Overexpression of extrasynaptic GABAA receptors decreases synaptic GABAergic transmission. Conclusion: Synaptic and extrasynaptic GABAA receptors may have intrinsic competition in single individual neurons. Significance: Phasic and tonic inhibition interacts to maintain homeostasis of total inhibition.

UR - http://www.scopus.com/inward/record.url?scp=84883320782&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883320782&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.491464

DO - 10.1074/jbc.M113.491464

M3 - Article

C2 - 23839941

AN - SCOPUS:84883320782

VL - 288

SP - 25053

EP - 25065

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 35

ER -