Homeostatic competition between phasic and tonic inhibition

Xia Wu, Lanting Huang, Zheng Wu, Ce Zhang, Dongyun Jiang, Yuting Bai, Yun Wang, Gong Chen

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Background: Synaptic and extrasynaptic GABAA receptors mediate phasic and tonic inhibition, respectively. Results: Overexpression of extrasynaptic GABAA receptors decreases synaptic GABAergic transmission. Conclusion: Synaptic and extrasynaptic GABAA receptors may have intrinsic competition in single individual neurons. Significance: Phasic and tonic inhibition interacts to maintain homeostasis of total inhibition.

Original languageEnglish (US)
Pages (from-to)25053-25065
Number of pages13
JournalJournal of Biological Chemistry
Volume288
Issue number35
DOIs
StatePublished - Aug 30 2013

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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