Homology-independent protein engineering

Stefan Lutz; Stephen J. Benkovic

doi:10.1016/S0958-1669(00)00106-3

Homology-independent protein engineering

Stefan Lutz, Stephen J. Benkovic

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Is structure, rather than sequence, the key to the successful generation of truly novel proteins? While protein evolution by homologous recombination has become an established tool to explore confined regions in sequence space, the generation of functional hybrid proteins by homology-independent methods further expands the scope of protein engineering.

Original language	English (US)
Pages (from-to)	319-324
Number of pages	6
Journal	Current Opinion in Biotechnology
Volume	11
Issue number	4
DOIs	https://doi.org/10.1016/S0958-1669(00)00106-3
State	Published - Aug 1 2000

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Biomedical Engineering

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abstract = "Is structure, rather than sequence, the key to the successful generation of truly novel proteins? While protein evolution by homologous recombination has become an established tool to explore confined regions in sequence space, the generation of functional hybrid proteins by homology-independent methods further expands the scope of protein engineering.",

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