Homology-independent protein engineering

Stefan Lutz, Stephen J. Benkovic

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Is structure, rather than sequence, the key to the successful generation of truly novel proteins? While protein evolution by homologous recombination has become an established tool to explore confined regions in sequence space, the generation of functional hybrid proteins by homology-independent methods further expands the scope of protein engineering.

Original languageEnglish (US)
Pages (from-to)319-324
Number of pages6
JournalCurrent Opinion in Biotechnology
Volume11
Issue number4
DOIs
Publication statusPublished - Aug 1 2000

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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