TY - JOUR
T1 - Homology-independent protein engineering
AU - Lutz, Stefan
AU - Benkovic, Stephen J.
N1 - Funding Information:
We thank M Ostermeier for helpful discussion and critical review of the paper. Stefan Lutz is recipient of a postdoctoral fellowship from the Swiss National Science Foundation.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2000/8/1
Y1 - 2000/8/1
N2 - Is structure, rather than sequence, the key to the successful generation of truly novel proteins? While protein evolution by homologous recombination has become an established tool to explore confined regions in sequence space, the generation of functional hybrid proteins by homology-independent methods further expands the scope of protein engineering.
AB - Is structure, rather than sequence, the key to the successful generation of truly novel proteins? While protein evolution by homologous recombination has become an established tool to explore confined regions in sequence space, the generation of functional hybrid proteins by homology-independent methods further expands the scope of protein engineering.
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U2 - 10.1016/S0958-1669(00)00106-3
DO - 10.1016/S0958-1669(00)00106-3
M3 - Review article
C2 - 10975450
AN - SCOPUS:0033894277
VL - 11
SP - 319
EP - 324
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
SN - 0958-1669
IS - 4
ER -