The relationship between an individual amino acid sequence and its associated protein structure is deterministic, but has proved to be too subtle to understand in detail from studying the relationships between single amino acid sequences and structures. The patterns that appear in tables of aligned homologous sequences contain much more information, and study of them has led to success in several applications. These include: a priori predictions of secondary and tertiary structure, screening an amino acid sequence database for proteins that share a folding pattern with a probe molecule, and distinguishing between correct protein structures and erroneous ones.
All Science Journal Classification (ASJC) codes
- Structural Biology
- Molecular Biology