Hormonal control of polyamine pools in experimental breast cancer in vivo: Correlation with estrogen and progesterone receptor levels

Andrea Manni, Betty Badger, James Lynch, Patricia Glikman, Laurence Demers

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The present experiments were designed to test whether, in the hormone responsive N-nitrosomethyl-urea (NMU)-induced rat mammary tumor, polyamine levels are under hormonal control and whether they correlate with estrogen (ER) and progesterone (PgR) receptor content. We observed that tumor regression induced by ovariectomy was associated with a decline in putrescine (Pu), spermidine (Sd) and spermine (Sm). Administration of estradiol and perphenazine (to stimulate endogenous prolactin release) to castrated rats restored tumor growth and contents of Pu and Sd to control values in a time dependent fashion while Sm levels were only modestly raised. The hormonal modulation of tumor polyamine levels was particularly obvious when the treatment effects on total pools (i.e. Pu+Sd+Sm) were analyzed. No significant correlation was observed between ER and PgR and polyamines in the tumors of intact rats as well as most of the treated groups. In contrast, a highly significant correlation was observed between ER and PgR levels. We conclude that in this experimental system cellular polyamine levels are hormonally regulated but are not correlated with the ER and PgR content of the tumor.

Original languageEnglish (US)
Pages (from-to)227-234
Number of pages8
JournalBreast Cancer Research and Treatment
Volume14
Issue number2
DOIs
StatePublished - Nov 1 1989

Fingerprint

Polyamines
Progesterone Receptors
Estrogen Receptors
Putrescine
Spermidine
Spermine
Breast Neoplasms
Progesterone
Estrogens
Neoplasms
Perphenazine
Ovariectomy
Prolactin
Urea
Estradiol
Hormones
Growth

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

@article{72b3eeab13d3431a92c98a62b7a73e18,
title = "Hormonal control of polyamine pools in experimental breast cancer in vivo: Correlation with estrogen and progesterone receptor levels",
abstract = "The present experiments were designed to test whether, in the hormone responsive N-nitrosomethyl-urea (NMU)-induced rat mammary tumor, polyamine levels are under hormonal control and whether they correlate with estrogen (ER) and progesterone (PgR) receptor content. We observed that tumor regression induced by ovariectomy was associated with a decline in putrescine (Pu), spermidine (Sd) and spermine (Sm). Administration of estradiol and perphenazine (to stimulate endogenous prolactin release) to castrated rats restored tumor growth and contents of Pu and Sd to control values in a time dependent fashion while Sm levels were only modestly raised. The hormonal modulation of tumor polyamine levels was particularly obvious when the treatment effects on total pools (i.e. Pu+Sd+Sm) were analyzed. No significant correlation was observed between ER and PgR and polyamines in the tumors of intact rats as well as most of the treated groups. In contrast, a highly significant correlation was observed between ER and PgR levels. We conclude that in this experimental system cellular polyamine levels are hormonally regulated but are not correlated with the ER and PgR content of the tumor.",
author = "Andrea Manni and Betty Badger and James Lynch and Patricia Glikman and Laurence Demers",
year = "1989",
month = "11",
day = "1",
doi = "10.1007/BF01810739",
language = "English (US)",
volume = "14",
pages = "227--234",
journal = "Breast Cancer Research and Treatment",
issn = "0167-6806",
publisher = "Springer New York",
number = "2",

}

Hormonal control of polyamine pools in experimental breast cancer in vivo : Correlation with estrogen and progesterone receptor levels. / Manni, Andrea; Badger, Betty; Lynch, James; Glikman, Patricia; Demers, Laurence.

In: Breast Cancer Research and Treatment, Vol. 14, No. 2, 01.11.1989, p. 227-234.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hormonal control of polyamine pools in experimental breast cancer in vivo

T2 - Correlation with estrogen and progesterone receptor levels

AU - Manni, Andrea

AU - Badger, Betty

AU - Lynch, James

AU - Glikman, Patricia

AU - Demers, Laurence

PY - 1989/11/1

Y1 - 1989/11/1

N2 - The present experiments were designed to test whether, in the hormone responsive N-nitrosomethyl-urea (NMU)-induced rat mammary tumor, polyamine levels are under hormonal control and whether they correlate with estrogen (ER) and progesterone (PgR) receptor content. We observed that tumor regression induced by ovariectomy was associated with a decline in putrescine (Pu), spermidine (Sd) and spermine (Sm). Administration of estradiol and perphenazine (to stimulate endogenous prolactin release) to castrated rats restored tumor growth and contents of Pu and Sd to control values in a time dependent fashion while Sm levels were only modestly raised. The hormonal modulation of tumor polyamine levels was particularly obvious when the treatment effects on total pools (i.e. Pu+Sd+Sm) were analyzed. No significant correlation was observed between ER and PgR and polyamines in the tumors of intact rats as well as most of the treated groups. In contrast, a highly significant correlation was observed between ER and PgR levels. We conclude that in this experimental system cellular polyamine levels are hormonally regulated but are not correlated with the ER and PgR content of the tumor.

AB - The present experiments were designed to test whether, in the hormone responsive N-nitrosomethyl-urea (NMU)-induced rat mammary tumor, polyamine levels are under hormonal control and whether they correlate with estrogen (ER) and progesterone (PgR) receptor content. We observed that tumor regression induced by ovariectomy was associated with a decline in putrescine (Pu), spermidine (Sd) and spermine (Sm). Administration of estradiol and perphenazine (to stimulate endogenous prolactin release) to castrated rats restored tumor growth and contents of Pu and Sd to control values in a time dependent fashion while Sm levels were only modestly raised. The hormonal modulation of tumor polyamine levels was particularly obvious when the treatment effects on total pools (i.e. Pu+Sd+Sm) were analyzed. No significant correlation was observed between ER and PgR and polyamines in the tumors of intact rats as well as most of the treated groups. In contrast, a highly significant correlation was observed between ER and PgR levels. We conclude that in this experimental system cellular polyamine levels are hormonally regulated but are not correlated with the ER and PgR content of the tumor.

UR - http://www.scopus.com/inward/record.url?scp=0024368472&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024368472&partnerID=8YFLogxK

U2 - 10.1007/BF01810739

DO - 10.1007/BF01810739

M3 - Article

C2 - 2605349

AN - SCOPUS:0024368472

VL - 14

SP - 227

EP - 234

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 2

ER -