Hormonal control of polyamine pools in experimental breast cancer in vivo: Correlation with estrogen and progesterone receptor levels

Andrea Manni, Betty Badger, James Lynch, Patricia Glikman, Laurence Demers

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4 Scopus citations

Abstract

The present experiments were designed to test whether, in the hormone responsive N-nitrosomethyl-urea (NMU)-induced rat mammary tumor, polyamine levels are under hormonal control and whether they correlate with estrogen (ER) and progesterone (PgR) receptor content. We observed that tumor regression induced by ovariectomy was associated with a decline in putrescine (Pu), spermidine (Sd) and spermine (Sm). Administration of estradiol and perphenazine (to stimulate endogenous prolactin release) to castrated rats restored tumor growth and contents of Pu and Sd to control values in a time dependent fashion while Sm levels were only modestly raised. The hormonal modulation of tumor polyamine levels was particularly obvious when the treatment effects on total pools (i.e. Pu+Sd+Sm) were analyzed. No significant correlation was observed between ER and PgR and polyamines in the tumors of intact rats as well as most of the treated groups. In contrast, a highly significant correlation was observed between ER and PgR levels. We conclude that in this experimental system cellular polyamine levels are hormonally regulated but are not correlated with the ER and PgR content of the tumor.

Original languageEnglish (US)
Pages (from-to)227-234
Number of pages8
JournalBreast Cancer Research and Treatment
Volume14
Issue number2
DOIs
StatePublished - Nov 1989

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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