Hormonal therapies for acne

Brittany Barros, Diane Thiboutot

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Acne is a common, worldwide problem that is usually multifactorial in etiology, but androgens may play a pivotal role in the development and severity of acne. Endocrinopathies, such as polycystic ovarian syndrome, ovarian tumors, or adrenal hyperplasia or tumors, may be detected in some patients with acne, especially if acne is sudden in onset, associated with hirsutism or menstrual irregularities, or associated with cushingoid facies, acanthosis nigricans, patterned hair loss, or deepened voice. In these instances, serum-free and total testosterone, dehydroepiandrosterone, luteinizing hormone, and follicle stimulating hormone should be tested. Appropriate referral and long-term follow-up is warranted in patients diagnosed with an endocrinopathy. Hormonal therapies for acne include systemic medications with various mechanisms: androgen receptor blockers, adrenal androgen production blockers, or ovarian androgen production blockers. Androgen receptor blockers include spironolactone, cyproterone acetate, chlormadinone, and flutamide; adrenal androgen production blockers include glucocorticoids; and ovarian production blockers include gonadotropin-releasing agonists and oral contraceptives. Practical guidelines are shared for the practicing physician treating hormonally related acne.

Original languageEnglish (US)
Pages (from-to)168-172
Number of pages5
JournalClinics in Dermatology
Volume35
Issue number2
DOIs
StatePublished - Mar 1 2017

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Acne Vulgaris
Androgens
Androgen Receptors
Therapeutics
Chlormadinone Acetate
Acanthosis Nigricans
Flutamide
Cyproterone Acetate
Hirsutism
Spironolactone
Dehydroepiandrosterone
Polycystic Ovary Syndrome
Alopecia
Follicle Stimulating Hormone
Oral Contraceptives
Luteinizing Hormone
Gonadotropins
Glucocorticoids
Hyperplasia
Testosterone

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Barros, Brittany ; Thiboutot, Diane. / Hormonal therapies for acne. In: Clinics in Dermatology. 2017 ; Vol. 35, No. 2. pp. 168-172.
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Hormonal therapies for acne. / Barros, Brittany; Thiboutot, Diane.

In: Clinics in Dermatology, Vol. 35, No. 2, 01.03.2017, p. 168-172.

Research output: Contribution to journalArticle

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