Hormonal Therapy for Acne

Rosalyn George, Shari Clarke, Diane Thiboutot

Research output: Contribution to journalReview article

67 Citations (Scopus)

Abstract

Acne affects more than 40 million people, of which more than half are women older than 25 years of age. These women frequently fail traditional therapy and have high relapse rates even after isotretinoin. Recent advances in research have helped to delineate the important role hormones play in the pathogenesis of acne. Androgens such as dihydrotestosterone and testosterone, the adrenal precursor dehydroepiandrosterone sulfate, estrogens, growth hormone, and insulin-like growth factors may all contribute to the development of acne. Hormonal therapy remains an important part of the arsenal of acne treatments available to the clinician. Women dealing with acne, even those without increased serum androgens, may benefit from hormonal treatments. The mainstays of hormonal therapy include oral contraceptives and antiandrogens such as spironolactone, cyproterone acetate, or flutamide. In this article, we discuss the effects of hormones on the pathogenesis of acne, evaluation of women with suspected endocrine abnormalities, and the myriad of treatment options available.

Original languageEnglish (US)
Pages (from-to)188-196
Number of pages9
JournalSeminars in Cutaneous Medicine and Surgery
Volume27
Issue number3
DOIs
StatePublished - Sep 1 2008

Fingerprint

Acne Vulgaris
Androgens
Therapeutics
Hormones
Flutamide
Cyproterone Acetate
Androgen Antagonists
Isotretinoin
Dehydroepiandrosterone Sulfate
Spironolactone
Dihydrotestosterone
Somatomedins
Oral Contraceptives
Growth Hormone
Testosterone
Estrogens
Recurrence
Serum
Research

All Science Journal Classification (ASJC) codes

  • Surgery
  • Dermatology

Cite this

George, Rosalyn ; Clarke, Shari ; Thiboutot, Diane. / Hormonal Therapy for Acne. In: Seminars in Cutaneous Medicine and Surgery. 2008 ; Vol. 27, No. 3. pp. 188-196.
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Hormonal Therapy for Acne. / George, Rosalyn; Clarke, Shari; Thiboutot, Diane.

In: Seminars in Cutaneous Medicine and Surgery, Vol. 27, No. 3, 01.09.2008, p. 188-196.

Research output: Contribution to journalReview article

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