Hormone changes in peripubertal girls

Frank M. Biro, Susan M. Pinney, Bin Huang, Erin R. Baker, Donald Walt Chandler, Lorah D. Dorn

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Context: Studies of hormone changes in the peripubertal period note increases in adrenal hormones prior to increases in sex steroids. It is unclear how these processes are related to each other, except through this temporal relationship.

Setting and Design: Longitudinal observation study. School districts, at the Cincinnati site of the Breast Cancer and the Environment Research Centers, between 2004-2010. Participants were recruited between ages 6 and 7 years of age and were seen every 6 months. Main outcome measures included height, weight, maturation status, and fasting blood specimen. Serum was analyzed for selected hormones every six months, beginning 30 months prior to, and extending to 6 months after, breast development. Androstenedione, estradiol, estrone, and T were measured by high-performance liquid chromatography (HPLC) with tandem mass spectrometry. Dehydroepiandrosterone-sulfate (DHEA-S) and SHBG also were measured.

Objective: Examine relationships in adrenal and sex hormones in 252 peripubertal girls.

Results: DHEA-S concentrations increased 24 months before breast development; androstenedione and estrone between 12 to 18 months before breast development; where as estradiol and T increased, and SHBG fell between 6 and 12 months before breast development. Girls with greater body mass index had lower estradiol concentrations at onset of breast development as well as 6 months after pubertal onset.

Conclusions: Serum estrone and DHEA-S increased prior to estradiol concentrations, and the increase in estradiol occurred prior to breast development. Heavier peripubertal girls have lower estradiol levels at puberty, suggesting peripheral conversion of adrenal androgens to estrone.

Original languageEnglish (US)
Pages (from-to)3829-3835
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume99
Issue number10
DOIs
StatePublished - Oct 1 2014

Fingerprint

Estradiol
Breast
Hormones
Dehydroepiandrosterone Sulfate
Estrone
Androstenedione
High performance liquid chromatography
Gonadal Steroid Hormones
Puberty
Tandem Mass Spectrometry
Serum
Androgens
Mass spectrometry
Longitudinal Studies
Fasting
Body Mass Index
Blood
Steroids
High Pressure Liquid Chromatography
Observation

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Biro, F. M., Pinney, S. M., Huang, B., Baker, E. R., Chandler, D. W., & Dorn, L. D. (2014). Hormone changes in peripubertal girls. Journal of Clinical Endocrinology and Metabolism, 99(10), 3829-3835. https://doi.org/10.1210/jc.2013-4528
Biro, Frank M. ; Pinney, Susan M. ; Huang, Bin ; Baker, Erin R. ; Chandler, Donald Walt ; Dorn, Lorah D. / Hormone changes in peripubertal girls. In: Journal of Clinical Endocrinology and Metabolism. 2014 ; Vol. 99, No. 10. pp. 3829-3835.
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Biro, FM, Pinney, SM, Huang, B, Baker, ER, Chandler, DW & Dorn, LD 2014, 'Hormone changes in peripubertal girls', Journal of Clinical Endocrinology and Metabolism, vol. 99, no. 10, pp. 3829-3835. https://doi.org/10.1210/jc.2013-4528

Hormone changes in peripubertal girls. / Biro, Frank M.; Pinney, Susan M.; Huang, Bin; Baker, Erin R.; Chandler, Donald Walt; Dorn, Lorah D.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 99, No. 10, 01.10.2014, p. 3829-3835.

Research output: Contribution to journalArticle

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AU - Biro, Frank M.

AU - Pinney, Susan M.

AU - Huang, Bin

AU - Baker, Erin R.

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AU - Dorn, Lorah D.

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N2 - Context: Studies of hormone changes in the peripubertal period note increases in adrenal hormones prior to increases in sex steroids. It is unclear how these processes are related to each other, except through this temporal relationship.Setting and Design: Longitudinal observation study. School districts, at the Cincinnati site of the Breast Cancer and the Environment Research Centers, between 2004-2010. Participants were recruited between ages 6 and 7 years of age and were seen every 6 months. Main outcome measures included height, weight, maturation status, and fasting blood specimen. Serum was analyzed for selected hormones every six months, beginning 30 months prior to, and extending to 6 months after, breast development. Androstenedione, estradiol, estrone, and T were measured by high-performance liquid chromatography (HPLC) with tandem mass spectrometry. Dehydroepiandrosterone-sulfate (DHEA-S) and SHBG also were measured.Objective: Examine relationships in adrenal and sex hormones in 252 peripubertal girls.Results: DHEA-S concentrations increased 24 months before breast development; androstenedione and estrone between 12 to 18 months before breast development; where as estradiol and T increased, and SHBG fell between 6 and 12 months before breast development. Girls with greater body mass index had lower estradiol concentrations at onset of breast development as well as 6 months after pubertal onset.Conclusions: Serum estrone and DHEA-S increased prior to estradiol concentrations, and the increase in estradiol occurred prior to breast development. Heavier peripubertal girls have lower estradiol levels at puberty, suggesting peripheral conversion of adrenal androgens to estrone.

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