Hormone therapy is associated with preserved smooth muscle structure and dilation in the arterial vasculature of the leg in older women

Beth A. Parker, Sandra L. Smithmyer, David Nathan Proctor

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Long-term hormone therapy (HT) is associated with reduced intima-medial thickness (IMT), an established risk factor for atherosclerotic disease, in the femoral artery of healthy older women relative to age-matched non-hormone users. However, the influence of continuous, long-term HT on the relation between age, IMT, and smooth muscle dilation has not been investigated in the popliteal artery, an artery prone to stiffening and calcification. In the present study, popliteal artery IMT and smooth muscle dilation (the increase in diameter to sublingual nitroglycerin, NTG) were assessed with Doppler ultrasound in young (Y: n = 16; age 23 ± 1 [mean ± S.E.M.]), older non-HT (O non-HT: n = 14; age 69 ± 1), and older HT (O HT: n = 8; age 67 ± 1) healthy women. The ∼0.5 mm increase in resting diameter observed in older non-HT women relative to young women was absent in older HT women, as was the age-related increase in IMT (Y: 0.52 ± 0.02 mm; O non-HT: 0.63 ± 0.02 mm; O HT: 0.56 ± 0.02 mm; p < 0.05 for age and hormone comparisons). NTG dilation (percent change above rest) was similarly attenuated in older non-HT women (Y: 8.6 ± 1%; O non-HT: 3.0 ± 0.7%; O HT: 7.4 ± 1.7%; p < 0.05 for age and hormone comparisons), and NTG dilation was inversely related to IMT (p < 0.01). Collectively, these results suggest that long-term, continuous HT may alleviate the detrimental effects of aging on both structural changes and smooth muscle dilation of the popliteal artery in healthy women.

Original languageEnglish (US)
Pages (from-to)46-54
Number of pages9
JournalMaturitas
Volume59
Issue number1
DOIs
StatePublished - Jan 20 2008

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Smooth Muscle
Muscle
Dilatation
Leg
Hormones
Popliteal Artery
Therapeutics
Nitroglycerin
Doppler Ultrasonography
Aging of materials
Ultrasonics
Femoral Artery
Scanning electron microscopy
Arteries

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Obstetrics and Gynecology

Cite this

@article{18e8ca9e6a8b4b3eb621ad8685ef7398,
title = "Hormone therapy is associated with preserved smooth muscle structure and dilation in the arterial vasculature of the leg in older women",
abstract = "Long-term hormone therapy (HT) is associated with reduced intima-medial thickness (IMT), an established risk factor for atherosclerotic disease, in the femoral artery of healthy older women relative to age-matched non-hormone users. However, the influence of continuous, long-term HT on the relation between age, IMT, and smooth muscle dilation has not been investigated in the popliteal artery, an artery prone to stiffening and calcification. In the present study, popliteal artery IMT and smooth muscle dilation (the increase in diameter to sublingual nitroglycerin, NTG) were assessed with Doppler ultrasound in young (Y: n = 16; age 23 ± 1 [mean ± S.E.M.]), older non-HT (O non-HT: n = 14; age 69 ± 1), and older HT (O HT: n = 8; age 67 ± 1) healthy women. The ∼0.5 mm increase in resting diameter observed in older non-HT women relative to young women was absent in older HT women, as was the age-related increase in IMT (Y: 0.52 ± 0.02 mm; O non-HT: 0.63 ± 0.02 mm; O HT: 0.56 ± 0.02 mm; p < 0.05 for age and hormone comparisons). NTG dilation (percent change above rest) was similarly attenuated in older non-HT women (Y: 8.6 ± 1{\%}; O non-HT: 3.0 ± 0.7{\%}; O HT: 7.4 ± 1.7{\%}; p < 0.05 for age and hormone comparisons), and NTG dilation was inversely related to IMT (p < 0.01). Collectively, these results suggest that long-term, continuous HT may alleviate the detrimental effects of aging on both structural changes and smooth muscle dilation of the popliteal artery in healthy women.",
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Hormone therapy is associated with preserved smooth muscle structure and dilation in the arterial vasculature of the leg in older women. / Parker, Beth A.; Smithmyer, Sandra L.; Proctor, David Nathan.

In: Maturitas, Vol. 59, No. 1, 20.01.2008, p. 46-54.

Research output: Contribution to journalArticle

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AB - Long-term hormone therapy (HT) is associated with reduced intima-medial thickness (IMT), an established risk factor for atherosclerotic disease, in the femoral artery of healthy older women relative to age-matched non-hormone users. However, the influence of continuous, long-term HT on the relation between age, IMT, and smooth muscle dilation has not been investigated in the popliteal artery, an artery prone to stiffening and calcification. In the present study, popliteal artery IMT and smooth muscle dilation (the increase in diameter to sublingual nitroglycerin, NTG) were assessed with Doppler ultrasound in young (Y: n = 16; age 23 ± 1 [mean ± S.E.M.]), older non-HT (O non-HT: n = 14; age 69 ± 1), and older HT (O HT: n = 8; age 67 ± 1) healthy women. The ∼0.5 mm increase in resting diameter observed in older non-HT women relative to young women was absent in older HT women, as was the age-related increase in IMT (Y: 0.52 ± 0.02 mm; O non-HT: 0.63 ± 0.02 mm; O HT: 0.56 ± 0.02 mm; p < 0.05 for age and hormone comparisons). NTG dilation (percent change above rest) was similarly attenuated in older non-HT women (Y: 8.6 ± 1%; O non-HT: 3.0 ± 0.7%; O HT: 7.4 ± 1.7%; p < 0.05 for age and hormone comparisons), and NTG dilation was inversely related to IMT (p < 0.01). Collectively, these results suggest that long-term, continuous HT may alleviate the detrimental effects of aging on both structural changes and smooth muscle dilation of the popliteal artery in healthy women.

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