Host-determined T cell fine specificity for self-H-2 in radiation bone-marrow chimeras of standard C57BL/6 (H-2b) mutant Hz1 (H-2ba), and F1 mice

Rolf M. Zinkernagel, Paul A. Klein, Jan Klein

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Reciprocal radiation bone-marrow chimeras were produced between the standard C57BL/6 (=B6) and the mutant B6.C -H-2ba (=Hz1) strain. When infected with vaccinia virus, these chimeras, as well as an (Hz1 × B6)=→ Hz1 chimera, produced cytotoxic cells that killed vaccinia-infected H-2KkH-2Db target cells but failed to kill virus-infected H-2KbH-2Dd cells. Virus-infected (Hz1 × B6)F1 → B6 chimeras, however, killed both types of target. These experiments demonstrate strict T-cell specificity capable of differentiating between two molecules that apparently differ by a single amino acid substitution.

Original languageEnglish (US)
Pages (from-to)73-77
Number of pages5
JournalImmunogenetics
Volume7
Issue number1
DOIs
StatePublished - Dec 1 1978

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics

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