Host immune status affects maturation time in two nematode species - But not as predicted by a simple life-history model

M. A. Guinnee, A. W. Gemmill, B. H.K. Chan, M. E. Viney, A. F. Read

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In theory, the age at which maturation occurs in parasitic nematodes is inversely related to pre-maturational mortality rate, and cross-species data on mammalian nematodes are consistent with this prediction. Immunity is a major source of parasite mortality and parasites stand to gain sizeable fitness benefits through short-term adjustments of maturation time in response to variation in immune-mediated mortality. The effects of thymus-dependent immune responses on maturation in the nematode parasites Strongyloides ratti and Nippostrongylus brasiliensis were investigated using congenitally thymus-deficient (nude) rats. As compared with worms in normal rats, reproductive maturity of parasites (presence of eggs in utero) in nude rats occurred later in 5. ratti but earlier in N. brasiliensis. Immune-mediated differences in maturation time were not associated with differences in worm length. Thymus-dependent immunity had no effect on prematurational mortality. Results are discussed in relation to theoretical expectations and possible explanations for the observed patterns in parasite maturation.

Original languageEnglish (US)
Pages (from-to)507-512
Number of pages6
JournalParasitology
Volume127
Issue number5
DOIs
StatePublished - Nov 1 2003

Fingerprint

Parasites
life history
Nematoda
parasites
Nippostrongylus brasiliensis
Nude Rats
Thymus Gland
Rattus
Mortality
Immunity
rats
Strongyloides ratti
immunity
Nippostrongylus
animal parasitic nematodes
Strongyloides
sexual maturity
Eggs
immune response
prediction

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Animal Science and Zoology
  • Infectious Diseases

Cite this

Guinnee, M. A. ; Gemmill, A. W. ; Chan, B. H.K. ; Viney, M. E. ; Read, A. F. / Host immune status affects maturation time in two nematode species - But not as predicted by a simple life-history model. In: Parasitology. 2003 ; Vol. 127, No. 5. pp. 507-512.
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Host immune status affects maturation time in two nematode species - But not as predicted by a simple life-history model. / Guinnee, M. A.; Gemmill, A. W.; Chan, B. H.K.; Viney, M. E.; Read, A. F.

In: Parasitology, Vol. 127, No. 5, 01.11.2003, p. 507-512.

Research output: Contribution to journalArticle

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