Abstract
Luo et al. find that the lncRNA HOTTIP is overexpressed in acute myeloid leukemia (AML). They show that HOTTIP coordinates topologically associated domain organization in the AML genome, including the posterior HOXA genes and various key hematopoietic regulator loci, and is important for AML growth.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 645-659.e8 |
| Journal | Cancer Cell |
| Volume | 36 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 9 2019 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cell Biology
- Cancer Research
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}
HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice. / Luo, Huacheng; Zhu, Ganqian; Xu, Jianfeng; Lai, Qian; Yan, Bowen; Guo, Ying; Fung, Tsz Kan; Zeisig, Bernd B.; Cui, Ya; Zha, Jie; Cogle, Christopher; Wang, Fei; Xu, Bing; Yang, Feng Chun; Li, Wei; So, Chi Wai Eric; Qiu, Yi; Xu, Mingjiang; Huang, Suming.
In: Cancer Cell, Vol. 36, No. 6, 09.12.2019, p. 645-659.e8.Research output: Contribution to journal › Article
TY - JOUR
T1 - HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice
AU - Luo, Huacheng
AU - Zhu, Ganqian
AU - Xu, Jianfeng
AU - Lai, Qian
AU - Yan, Bowen
AU - Guo, Ying
AU - Fung, Tsz Kan
AU - Zeisig, Bernd B.
AU - Cui, Ya
AU - Zha, Jie
AU - Cogle, Christopher
AU - Wang, Fei
AU - Xu, Bing
AU - Yang, Feng Chun
AU - Li, Wei
AU - So, Chi Wai Eric
AU - Qiu, Yi
AU - Xu, Mingjiang
AU - Huang, Suming
PY - 2019/12/9
Y1 - 2019/12/9
N2 - Luo et al. find that the lncRNA HOTTIP is overexpressed in acute myeloid leukemia (AML). They show that HOTTIP coordinates topologically associated domain organization in the AML genome, including the posterior HOXA genes and various key hematopoietic regulator loci, and is important for AML growth.
AB - Luo et al. find that the lncRNA HOTTIP is overexpressed in acute myeloid leukemia (AML). They show that HOTTIP coordinates topologically associated domain organization in the AML genome, including the posterior HOXA genes and various key hematopoietic regulator loci, and is important for AML growth.
UR - http://www.scopus.com/inward/record.url?scp=85075878690&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075878690&partnerID=8YFLogxK
U2 - 10.1016/j.ccell.2019.10.011
DO - 10.1016/j.ccell.2019.10.011
M3 - Article
C2 - 31786140
AN - SCOPUS:85075878690
VL - 36
SP - 645-659.e8
JO - Cancer Cell
JF - Cancer Cell
SN - 1535-6108
IS - 6
ER -