@article{19f1cc2f3ebb406ca06b54ffb0d28feb,
title = "HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice",
abstract = "Luo et al. find that the lncRNA HOTTIP is overexpressed in acute myeloid leukemia (AML). They show that HOTTIP coordinates topologically associated domain organization in the AML genome, including the posterior HOXA genes and various key hematopoietic regulator loci, and is important for AML growth.",
author = "Huacheng Luo and Ganqian Zhu and Jianfeng Xu and Qian Lai and Bowen Yan and Ying Guo and Fung, {Tsz Kan} and Zeisig, {Bernd B.} and Ya Cui and Jie Zha and Christopher Cogle and Fei Wang and Bing Xu and Yang, {Feng Chun} and Wei Li and So, {Chi Wai Eric} and Yi Qiu and Mingjiang Xu and Suming Huang",
note = "Funding Information: We thank Penn State College of Medicine Genome Science Facility. This work was supported by grants from National Institutes of Health (S.H., R01DK110108 , R01CA204044 , HL141950 ; M.X., R01CA172408 , R01HL145883 , R01HL141950 ; Y.Q., R01HL144712 ; W.L., R01HG007538 , R01CA228140 ), Program grants by Cancer Research UK and Bloodwise (C.W.E.S.), San Antonio Cancer Council (X.M.) and the Four Diamonds Fund (S.H.). ",
year = "2019",
month = dec,
day = "9",
doi = "10.1016/j.ccell.2019.10.011",
language = "English (US)",
volume = "36",
pages = "645--659.e8",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "6",
}