How does the genome structure and lifestyle of a virus affect its population variation?

Maliheh Safari, Marilyn J. Roossinck

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Viruses use diverse strategies for their replication, related in part to the genome structure (double-stranded or single-stranded; positive sense or negative sense; RNA or DNA). During each round of replication, mutations are introduced in the viral genome and the mode of replication (stamping machine and geometric replication) may affect the population dynamics of the progeny virus. Our understanding of the relationships among genome strandedness, mode of replication and the population variation is still limited. Here we will review what is known about virus replication by stamping machine or geometric modes, and how that relates to the biology of single stranded versus double stranded RNA genomes. We will present how this may affect the mutation frequency and population dynamics. Finally the potential importance of the population dynamics in acute viruses and persistent viruses will be discussed.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalCurrent Opinion in Virology
Volume9
DOIs
StatePublished - Dec 1 2014

Fingerprint

Life Style
Population Dynamics
Genome
Viruses
Population
Double-Stranded RNA
Viral Genome
Mutation Rate
Virus Replication
RNA
Mutation
DNA

All Science Journal Classification (ASJC) codes

  • Virology

Cite this

@article{f1c8554f0832412cb4e0eaa4bee67d20,
title = "How does the genome structure and lifestyle of a virus affect its population variation?",
abstract = "Viruses use diverse strategies for their replication, related in part to the genome structure (double-stranded or single-stranded; positive sense or negative sense; RNA or DNA). During each round of replication, mutations are introduced in the viral genome and the mode of replication (stamping machine and geometric replication) may affect the population dynamics of the progeny virus. Our understanding of the relationships among genome strandedness, mode of replication and the population variation is still limited. Here we will review what is known about virus replication by stamping machine or geometric modes, and how that relates to the biology of single stranded versus double stranded RNA genomes. We will present how this may affect the mutation frequency and population dynamics. Finally the potential importance of the population dynamics in acute viruses and persistent viruses will be discussed.",
author = "Maliheh Safari and Roossinck, {Marilyn J.}",
year = "2014",
month = "12",
day = "1",
doi = "10.1016/j.coviro.2014.09.004",
language = "English (US)",
volume = "9",
pages = "39--44",
journal = "Current Opinion in Virology",
issn = "1879-6257",
publisher = "Elsevier BV",

}

How does the genome structure and lifestyle of a virus affect its population variation? / Safari, Maliheh; Roossinck, Marilyn J.

In: Current Opinion in Virology, Vol. 9, 01.12.2014, p. 39-44.

Research output: Contribution to journalReview article

TY - JOUR

T1 - How does the genome structure and lifestyle of a virus affect its population variation?

AU - Safari, Maliheh

AU - Roossinck, Marilyn J.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Viruses use diverse strategies for their replication, related in part to the genome structure (double-stranded or single-stranded; positive sense or negative sense; RNA or DNA). During each round of replication, mutations are introduced in the viral genome and the mode of replication (stamping machine and geometric replication) may affect the population dynamics of the progeny virus. Our understanding of the relationships among genome strandedness, mode of replication and the population variation is still limited. Here we will review what is known about virus replication by stamping machine or geometric modes, and how that relates to the biology of single stranded versus double stranded RNA genomes. We will present how this may affect the mutation frequency and population dynamics. Finally the potential importance of the population dynamics in acute viruses and persistent viruses will be discussed.

AB - Viruses use diverse strategies for their replication, related in part to the genome structure (double-stranded or single-stranded; positive sense or negative sense; RNA or DNA). During each round of replication, mutations are introduced in the viral genome and the mode of replication (stamping machine and geometric replication) may affect the population dynamics of the progeny virus. Our understanding of the relationships among genome strandedness, mode of replication and the population variation is still limited. Here we will review what is known about virus replication by stamping machine or geometric modes, and how that relates to the biology of single stranded versus double stranded RNA genomes. We will present how this may affect the mutation frequency and population dynamics. Finally the potential importance of the population dynamics in acute viruses and persistent viruses will be discussed.

UR - http://www.scopus.com/inward/record.url?scp=84907932989&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907932989&partnerID=8YFLogxK

U2 - 10.1016/j.coviro.2014.09.004

DO - 10.1016/j.coviro.2014.09.004

M3 - Review article

C2 - 25243801

AN - SCOPUS:84907932989

VL - 9

SP - 39

EP - 44

JO - Current Opinion in Virology

JF - Current Opinion in Virology

SN - 1879-6257

ER -