How to facilitate early diagnosis of CNS involvement in malignant lymphoma

Agnieszka Korfel, Martha Nowosielski, Javier Pardo-Moreno, Francisco Javier Penalver, Gabriele Buda, Hind Bennani, Myrto Costopoulos, Magali Le Garff-Tavernier, Carole Soussain, Mathias Schmid, Jose Alberto Orfao, Michael Glantz

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Introduction: Making the diagnosis of secondary CNS involvement in lymphoma can be difficult due to unspecific signs and symptoms, limited accessibility of brain/myelon parenchyma and low sensitivity and/or specifity of imaging and cerebrospinal fluid (CSF) examination currently available. Areas covered: MRI of the total neuroaxis followed by CSF cytomorphology and flow cytometry are methods of choice when CNS lymphoma (CNSL) is suspected. To reduce the numerous pitfalls of these examinations several aspects should be considered. New CSF biomarkers might be of potential diagnostic value. Attempts to standardize response criteria are presented. Expert commentary: Diagnosing CNSL remains challenging. Until diagnostic methods combining high sensitivity with high specifity are routinely introduced, high level of awareness and optimal utilization of examinations currently available are needed to early diagnose this potentially devastating disease.

Original languageEnglish (US)
Pages (from-to)1081-1091
Number of pages11
JournalExpert Review of Hematology
Volume9
Issue number11
DOIs
Publication statusPublished - Nov 1 2016

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All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Korfel, A., Nowosielski, M., Pardo-Moreno, J., Penalver, F. J., Buda, G., Bennani, H., ... Glantz, M. (2016). How to facilitate early diagnosis of CNS involvement in malignant lymphoma. Expert Review of Hematology, 9(11), 1081-1091. https://doi.org/10.1080/17474086.2016.1242405