HPV Prevalence among Women from Appalachia: Results from the CARE Project

Paul L. Reiter, Mira L. Katz, Mack Ruffin, Erinn M. Hade, Cecilia R. DeGraffenreid, Divya A. Patel, Electra D. Paskett, Elizabeth R. Unger

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background:Cervical cancer incidence and mortality rates are high among women from Appalachia, yet data do not exist on human papillomavirus (HPV) prevalence among these women. We examined the prevalence of genital HPV among Appalachian women and identified correlates of HPV detection.Methods:We report data from a case-control study conducted between January 2006 and December 2008 as part of the Community Awareness, Resources, and Education (CARE) Project. We examined HPV prevalence among 1116 women (278 women with abnormal Pap tests at study entry [cases], 838 women with normal Pap tests [controls]) from Appalachian Ohio. Analyses used multivariable logistic regression to identify correlates of HPV detection.Results:The prevalence of HPV was 43.1% for any HPV type, 33.5% for high-risk HPV types, 23.4% for low-risk HPV types, and 12.5% for vaccine-preventable HPV types. Detection of any HPV type was more common among women who were ages 18-26 (OR = 2.09, 95% CI: 1.26-3.50), current smokers (OR = 1.86, 95% CI: 1.26-2.73), had at least five male sexual partners during their lifetime (OR = 2.28, 95% CI: 1.56-3.33), or had multiple male sexual partners during the last year (OR = 1.98, 95% CI: 1.25-3.14). Similar correlates were identified for detection of a high-risk HPV type.Conclusions:HPV was prevalent among Appalachian women, with many women having a high-risk HPV type detected. Results may help explain the high cervical cancer rates observed among Appalachian women and can help inform future cervical cancer prevention efforts in this geographic region.

Original languageEnglish (US)
Article numbere74276
JournalPloS one
Volume8
Issue number8
DOIs
StatePublished - Aug 30 2013

Fingerprint

Appalachian Region
Appalachian region
Papillomaviridae
education
Education
Papillomavirus Vaccines
uterine cervical neoplasms
Uterine Cervical Neoplasms
Logistics
Papanicolaou Test
Sexual Partners

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Reiter, P. L., Katz, M. L., Ruffin, M., Hade, E. M., DeGraffenreid, C. R., Patel, D. A., ... Unger, E. R. (2013). HPV Prevalence among Women from Appalachia: Results from the CARE Project. PloS one, 8(8), [e74276]. https://doi.org/10.1371/journal.pone.0074276
Reiter, Paul L. ; Katz, Mira L. ; Ruffin, Mack ; Hade, Erinn M. ; DeGraffenreid, Cecilia R. ; Patel, Divya A. ; Paskett, Electra D. ; Unger, Elizabeth R. / HPV Prevalence among Women from Appalachia : Results from the CARE Project. In: PloS one. 2013 ; Vol. 8, No. 8.
@article{3d370fecb82c419c8ad5707f7b22e78a,
title = "HPV Prevalence among Women from Appalachia: Results from the CARE Project",
abstract = "Background:Cervical cancer incidence and mortality rates are high among women from Appalachia, yet data do not exist on human papillomavirus (HPV) prevalence among these women. We examined the prevalence of genital HPV among Appalachian women and identified correlates of HPV detection.Methods:We report data from a case-control study conducted between January 2006 and December 2008 as part of the Community Awareness, Resources, and Education (CARE) Project. We examined HPV prevalence among 1116 women (278 women with abnormal Pap tests at study entry [cases], 838 women with normal Pap tests [controls]) from Appalachian Ohio. Analyses used multivariable logistic regression to identify correlates of HPV detection.Results:The prevalence of HPV was 43.1{\%} for any HPV type, 33.5{\%} for high-risk HPV types, 23.4{\%} for low-risk HPV types, and 12.5{\%} for vaccine-preventable HPV types. Detection of any HPV type was more common among women who were ages 18-26 (OR = 2.09, 95{\%} CI: 1.26-3.50), current smokers (OR = 1.86, 95{\%} CI: 1.26-2.73), had at least five male sexual partners during their lifetime (OR = 2.28, 95{\%} CI: 1.56-3.33), or had multiple male sexual partners during the last year (OR = 1.98, 95{\%} CI: 1.25-3.14). Similar correlates were identified for detection of a high-risk HPV type.Conclusions:HPV was prevalent among Appalachian women, with many women having a high-risk HPV type detected. Results may help explain the high cervical cancer rates observed among Appalachian women and can help inform future cervical cancer prevention efforts in this geographic region.",
author = "Reiter, {Paul L.} and Katz, {Mira L.} and Mack Ruffin and Hade, {Erinn M.} and DeGraffenreid, {Cecilia R.} and Patel, {Divya A.} and Paskett, {Electra D.} and Unger, {Elizabeth R.}",
year = "2013",
month = "8",
day = "30",
doi = "10.1371/journal.pone.0074276",
language = "English (US)",
volume = "8",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

Reiter, PL, Katz, ML, Ruffin, M, Hade, EM, DeGraffenreid, CR, Patel, DA, Paskett, ED & Unger, ER 2013, 'HPV Prevalence among Women from Appalachia: Results from the CARE Project', PloS one, vol. 8, no. 8, e74276. https://doi.org/10.1371/journal.pone.0074276

HPV Prevalence among Women from Appalachia : Results from the CARE Project. / Reiter, Paul L.; Katz, Mira L.; Ruffin, Mack; Hade, Erinn M.; DeGraffenreid, Cecilia R.; Patel, Divya A.; Paskett, Electra D.; Unger, Elizabeth R.

In: PloS one, Vol. 8, No. 8, e74276, 30.08.2013.

Research output: Contribution to journalArticle

TY - JOUR

T1 - HPV Prevalence among Women from Appalachia

T2 - Results from the CARE Project

AU - Reiter, Paul L.

AU - Katz, Mira L.

AU - Ruffin, Mack

AU - Hade, Erinn M.

AU - DeGraffenreid, Cecilia R.

AU - Patel, Divya A.

AU - Paskett, Electra D.

AU - Unger, Elizabeth R.

PY - 2013/8/30

Y1 - 2013/8/30

N2 - Background:Cervical cancer incidence and mortality rates are high among women from Appalachia, yet data do not exist on human papillomavirus (HPV) prevalence among these women. We examined the prevalence of genital HPV among Appalachian women and identified correlates of HPV detection.Methods:We report data from a case-control study conducted between January 2006 and December 2008 as part of the Community Awareness, Resources, and Education (CARE) Project. We examined HPV prevalence among 1116 women (278 women with abnormal Pap tests at study entry [cases], 838 women with normal Pap tests [controls]) from Appalachian Ohio. Analyses used multivariable logistic regression to identify correlates of HPV detection.Results:The prevalence of HPV was 43.1% for any HPV type, 33.5% for high-risk HPV types, 23.4% for low-risk HPV types, and 12.5% for vaccine-preventable HPV types. Detection of any HPV type was more common among women who were ages 18-26 (OR = 2.09, 95% CI: 1.26-3.50), current smokers (OR = 1.86, 95% CI: 1.26-2.73), had at least five male sexual partners during their lifetime (OR = 2.28, 95% CI: 1.56-3.33), or had multiple male sexual partners during the last year (OR = 1.98, 95% CI: 1.25-3.14). Similar correlates were identified for detection of a high-risk HPV type.Conclusions:HPV was prevalent among Appalachian women, with many women having a high-risk HPV type detected. Results may help explain the high cervical cancer rates observed among Appalachian women and can help inform future cervical cancer prevention efforts in this geographic region.

AB - Background:Cervical cancer incidence and mortality rates are high among women from Appalachia, yet data do not exist on human papillomavirus (HPV) prevalence among these women. We examined the prevalence of genital HPV among Appalachian women and identified correlates of HPV detection.Methods:We report data from a case-control study conducted between January 2006 and December 2008 as part of the Community Awareness, Resources, and Education (CARE) Project. We examined HPV prevalence among 1116 women (278 women with abnormal Pap tests at study entry [cases], 838 women with normal Pap tests [controls]) from Appalachian Ohio. Analyses used multivariable logistic regression to identify correlates of HPV detection.Results:The prevalence of HPV was 43.1% for any HPV type, 33.5% for high-risk HPV types, 23.4% for low-risk HPV types, and 12.5% for vaccine-preventable HPV types. Detection of any HPV type was more common among women who were ages 18-26 (OR = 2.09, 95% CI: 1.26-3.50), current smokers (OR = 1.86, 95% CI: 1.26-2.73), had at least five male sexual partners during their lifetime (OR = 2.28, 95% CI: 1.56-3.33), or had multiple male sexual partners during the last year (OR = 1.98, 95% CI: 1.25-3.14). Similar correlates were identified for detection of a high-risk HPV type.Conclusions:HPV was prevalent among Appalachian women, with many women having a high-risk HPV type detected. Results may help explain the high cervical cancer rates observed among Appalachian women and can help inform future cervical cancer prevention efforts in this geographic region.

UR - http://www.scopus.com/inward/record.url?scp=84883360366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883360366&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0074276

DO - 10.1371/journal.pone.0074276

M3 - Article

C2 - 24023700

AN - SCOPUS:84883360366

VL - 8

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 8

M1 - e74276

ER -

Reiter PL, Katz ML, Ruffin M, Hade EM, DeGraffenreid CR, Patel DA et al. HPV Prevalence among Women from Appalachia: Results from the CARE Project. PloS one. 2013 Aug 30;8(8). e74276. https://doi.org/10.1371/journal.pone.0074276