Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase

Jianming Hu, Christoph Seeger

Research output: Contribution to journalArticlepeer-review

276 Scopus citations

Abstract

The heat shock protein Hsp90 is known as an essential component of several signal transduction pathways and has now been identified as an essential host factor for hepatitis B virus replication. Hsp90 interacts with the viral reverse transcriptase to facilitate the formation of a ribonucleoprotein (RNP) complex between the polymerase and an RNA ligand. This RNP complex is required early in replication for viral assembly and initiation of DNA synthesis through a protein-priming mechanism. These results thus invoke a role for the Hsp90 pathway in the formation of an RNP.

Original languageEnglish (US)
Pages (from-to)1060-1064
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume93
Issue number3
DOIs
StatePublished - Feb 6 1996

All Science Journal Classification (ASJC) codes

  • General

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