Human adipose-derived stem cells and three-dimensional scaffold constructs: A review of the biomaterials and models currently used for bone regeneration

Andrea S. Zanetti, Cristina Sabliov, Jeffrey M. Gimble, Daniel J. Hayes

Research output: Contribution to journalReview article

54 Scopus citations

Abstract

In the past decade, substantial strides have been taken toward the use of human adipose-derived stromal/stem cells (hASC) in the regeneration of bone. Since the discovery of the hASC osteogenic potential, many models have combined hASC with biodegradable scaffold materials. In general, rats and immunodeficient (nude) mice models for nonweight bearing bone formation have led the way to assess hASC osteogenic potential in vivo. The goal of this review is to present an overview of the recent literature describing hASC osteogenesis in conjuction with three-dimensional scaffolds for bone regeneration.

Original languageEnglish (US)
Pages (from-to)187-199
Number of pages13
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume101 B
Issue number1
DOIs
StatePublished - Jan 1 2013

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

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