Human and mouse dopamine transporter genes: conservation of 5′-flanking sequence elements and gene structures

David M. Donovan, David J. Vandenbergh, Michael P. Perry, Geoffrey S. Bird, Roxann Ingersoll, Elizabeth Nanthakumar, George R. Uhl

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

Synaptic reaccumulation of the neurotransmitter dopamine is mediated by the dopamine transporter (DAT), a member of the family of twelve transmembrane domain, sodium- and chloride-dependent neurotransmitter transporters. Several DAT features, including its exclusive expression in dopaminergic neurons, implication in cocaine action, and prominent role in the mechanisms of Parkinsonism-inducing neurotoxins, make understanding of the DAT gene of interest. Isolation and characterization of the human and mouse DAT genes has allowed elucidation of similarities between each and other members of this transporter gene family. Sequences 5′ to transcriptional start sites contain G-C rich, TATA-less, CAAT-less regions with striking conservation between human and mouse gene flanking regions. These studies suggest sequence elements that are candidates to contribute to the dopamine transporter's dopaminergic cell-specific expression.

Original languageEnglish (US)
Pages (from-to)327-335
Number of pages9
JournalMolecular Brain Research
Volume30
Issue number2
DOIs
StatePublished - Jun 1995

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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