Human and mouse dopamine transporter genes

conservation of 5′-flanking sequence elements and gene structures

David M. Donovan, David John Vandenbergh, Michael P. Perry, Geoffrey S. Bird, Roxann Ingersoll, Elizabeth Nanthakumar, George R. Uhl

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Synaptic reaccumulation of the neurotransmitter dopamine is mediated by the dopamine transporter (DAT), a member of the family of twelve transmembrane domain, sodium- and chloride-dependent neurotransmitter transporters. Several DAT features, including its exclusive expression in dopaminergic neurons, implication in cocaine action, and prominent role in the mechanisms of Parkinsonism-inducing neurotoxins, make understanding of the DAT gene of interest. Isolation and characterization of the human and mouse DAT genes has allowed elucidation of similarities between each and other members of this transporter gene family. Sequences 5′ to transcriptional start sites contain G-C rich, TATA-less, CAAT-less regions with striking conservation between human and mouse gene flanking regions. These studies suggest sequence elements that are candidates to contribute to the dopamine transporter's dopaminergic cell-specific expression.

Original languageEnglish (US)
Pages (from-to)327-335
Number of pages9
JournalMolecular Brain Research
Volume30
Issue number2
DOIs
StatePublished - Jan 1 1995

Fingerprint

Dopamine Plasma Membrane Transport Proteins
5' Flanking Region
Genes
Neurotransmitter Transport Proteins
Dopaminergic Neurons
Neurotoxins
Parkinsonian Disorders
Cocaine
Sodium Chloride
Neurotransmitter Agents
Dopamine

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Donovan, David M. ; Vandenbergh, David John ; Perry, Michael P. ; Bird, Geoffrey S. ; Ingersoll, Roxann ; Nanthakumar, Elizabeth ; Uhl, George R. / Human and mouse dopamine transporter genes : conservation of 5′-flanking sequence elements and gene structures. In: Molecular Brain Research. 1995 ; Vol. 30, No. 2. pp. 327-335.
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Human and mouse dopamine transporter genes : conservation of 5′-flanking sequence elements and gene structures. / Donovan, David M.; Vandenbergh, David John; Perry, Michael P.; Bird, Geoffrey S.; Ingersoll, Roxann; Nanthakumar, Elizabeth; Uhl, George R.

In: Molecular Brain Research, Vol. 30, No. 2, 01.01.1995, p. 327-335.

Research output: Contribution to journalArticle

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