Human baroreflex rhythms persist during handgrip and muscle ischaemia

D. L. Eckberg, W. H. Cooke, A. Diedrich, B. D. Levine, James Anthony Pawelczyk, J. C. Buckey, A. C. Ertl, I. Biaggioni, J. F. Cox, D. Robertson, F. J. Baisch, C. G. Blomqvist, T. A. Kuusela, K. U O Tahvanainen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aim: To determine whether physiological, rhythmic fluctuations of vagal baroreflex gain persist during exercise, post-exercise ischaemia and recovery. Methods: We studied responses of six supine healthy men and one woman to a stereotyped protocol comprising rest, handgrip exercise at 40% maximum capacity to exhaustion, post-exercise forearm ischaemia and recovery. We measured electrocardiographic R-R intervals, photoplethysmographic finger arterial pressures and peroneal nerve muscle sympathetic activity. We derived vagal baroreflex gains from a sliding (25-s window moved by 2-s steps) systolic pressure-R-R interval transfer function at 0.04-0.15 Hz. Results: Vagal baroreflex gain oscillated at low, nearly constant frequencies throughout the protocol (at approx. 0.06 Hz - a period of about 18 s); however, during exercise, most oscillations were at low-gain levels, and during ischaemia and recovery, most oscillations were at high-gain levels. Conclusions: Vagal baroreflex rhythms are not abolished by exercise, and they are not overwhelmed after exercise during ischaemia and recovery. Published 2013. This article is a U.S. Government work and is in the public domain in the U.S.A.

Original languageEnglish (US)
Pages (from-to)114-123
Number of pages10
JournalActa Physiologica
Volume209
Issue number2
DOIs
StatePublished - Oct 1 2013

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Baroreflex
Ischemia
Exercise
Muscles
Peroneal Nerve
Public Sector
Forearm
Fingers
Arterial Pressure
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Physiology

Cite this

Eckberg, D. L., Cooke, W. H., Diedrich, A., Levine, B. D., Pawelczyk, J. A., Buckey, J. C., ... Tahvanainen, K. U. O. (2013). Human baroreflex rhythms persist during handgrip and muscle ischaemia. Acta Physiologica, 209(2), 114-123. https://doi.org/10.1111/apha.12143
Eckberg, D. L. ; Cooke, W. H. ; Diedrich, A. ; Levine, B. D. ; Pawelczyk, James Anthony ; Buckey, J. C. ; Ertl, A. C. ; Biaggioni, I. ; Cox, J. F. ; Robertson, D. ; Baisch, F. J. ; Blomqvist, C. G. ; Kuusela, T. A. ; Tahvanainen, K. U O. / Human baroreflex rhythms persist during handgrip and muscle ischaemia. In: Acta Physiologica. 2013 ; Vol. 209, No. 2. pp. 114-123.
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Eckberg, DL, Cooke, WH, Diedrich, A, Levine, BD, Pawelczyk, JA, Buckey, JC, Ertl, AC, Biaggioni, I, Cox, JF, Robertson, D, Baisch, FJ, Blomqvist, CG, Kuusela, TA & Tahvanainen, KUO 2013, 'Human baroreflex rhythms persist during handgrip and muscle ischaemia', Acta Physiologica, vol. 209, no. 2, pp. 114-123. https://doi.org/10.1111/apha.12143

Human baroreflex rhythms persist during handgrip and muscle ischaemia. / Eckberg, D. L.; Cooke, W. H.; Diedrich, A.; Levine, B. D.; Pawelczyk, James Anthony; Buckey, J. C.; Ertl, A. C.; Biaggioni, I.; Cox, J. F.; Robertson, D.; Baisch, F. J.; Blomqvist, C. G.; Kuusela, T. A.; Tahvanainen, K. U O.

In: Acta Physiologica, Vol. 209, No. 2, 01.10.2013, p. 114-123.

Research output: Contribution to journalArticle

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T1 - Human baroreflex rhythms persist during handgrip and muscle ischaemia

AU - Eckberg, D. L.

AU - Cooke, W. H.

AU - Diedrich, A.

AU - Levine, B. D.

AU - Pawelczyk, James Anthony

AU - Buckey, J. C.

AU - Ertl, A. C.

AU - Biaggioni, I.

AU - Cox, J. F.

AU - Robertson, D.

AU - Baisch, F. J.

AU - Blomqvist, C. G.

AU - Kuusela, T. A.

AU - Tahvanainen, K. U O

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Aim: To determine whether physiological, rhythmic fluctuations of vagal baroreflex gain persist during exercise, post-exercise ischaemia and recovery. Methods: We studied responses of six supine healthy men and one woman to a stereotyped protocol comprising rest, handgrip exercise at 40% maximum capacity to exhaustion, post-exercise forearm ischaemia and recovery. We measured electrocardiographic R-R intervals, photoplethysmographic finger arterial pressures and peroneal nerve muscle sympathetic activity. We derived vagal baroreflex gains from a sliding (25-s window moved by 2-s steps) systolic pressure-R-R interval transfer function at 0.04-0.15 Hz. Results: Vagal baroreflex gain oscillated at low, nearly constant frequencies throughout the protocol (at approx. 0.06 Hz - a period of about 18 s); however, during exercise, most oscillations were at low-gain levels, and during ischaemia and recovery, most oscillations were at high-gain levels. Conclusions: Vagal baroreflex rhythms are not abolished by exercise, and they are not overwhelmed after exercise during ischaemia and recovery. Published 2013. This article is a U.S. Government work and is in the public domain in the U.S.A.

AB - Aim: To determine whether physiological, rhythmic fluctuations of vagal baroreflex gain persist during exercise, post-exercise ischaemia and recovery. Methods: We studied responses of six supine healthy men and one woman to a stereotyped protocol comprising rest, handgrip exercise at 40% maximum capacity to exhaustion, post-exercise forearm ischaemia and recovery. We measured electrocardiographic R-R intervals, photoplethysmographic finger arterial pressures and peroneal nerve muscle sympathetic activity. We derived vagal baroreflex gains from a sliding (25-s window moved by 2-s steps) systolic pressure-R-R interval transfer function at 0.04-0.15 Hz. Results: Vagal baroreflex gain oscillated at low, nearly constant frequencies throughout the protocol (at approx. 0.06 Hz - a period of about 18 s); however, during exercise, most oscillations were at low-gain levels, and during ischaemia and recovery, most oscillations were at high-gain levels. Conclusions: Vagal baroreflex rhythms are not abolished by exercise, and they are not overwhelmed after exercise during ischaemia and recovery. Published 2013. This article is a U.S. Government work and is in the public domain in the U.S.A.

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Eckberg DL, Cooke WH, Diedrich A, Levine BD, Pawelczyk JA, Buckey JC et al. Human baroreflex rhythms persist during handgrip and muscle ischaemia. Acta Physiologica. 2013 Oct 1;209(2):114-123. https://doi.org/10.1111/apha.12143