The acute "in vitro" effects of human chorionic gonadotropin (HCG) and protaglandin E2 on human placental glycogen metabolism have been studied in immature placental villi in short-term culture. HCG elicited within 15 min of culture, an acute glycogenolytic response in placental tissue which included a decrease in placental glycogen, an activation of the glycogen phosphorylase enzyme system and a pronounced elevation in the cyclic AMP concentration of the placenta. The presence of prostaglandin E2 in the culture medium evoked a similar glycogenolytic effect in immature human placental villi including the increase in tissue cyclic AMP levels. These findings suggest a second messenger role of the prostaglandins in HCG action and results are discussed in light of the mechanism of action of HCG on the human placenta.
All Science Journal Classification (ASJC) codes
- Molecular Biology