Human chorionic gonadotropin-mediated glycogenolysis in human placental villi: A role of prostaglandins

Laurence M. Demers; Steven G. Gabbe; Claude A. Villee; Roy O. Greep

doi:10.1016/0304-4165(73)90201-8

Human chorionic gonadotropin-mediated glycogenolysis in human placental villi: A role of prostaglandins

Laurence M. Demers, Steven G. Gabbe, Claude A. Villee, Roy O. Greep

Department of Pathology and Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The acute "in vitro" effects of human chorionic gonadotropin (HCG) and protaglandin E2 on human placental glycogen metabolism have been studied in immature placental villi in short-term culture. HCG elicited within 15 min of culture, an acute glycogenolytic response in placental tissue which included a decrease in placental glycogen, an activation of the glycogen phosphorylase enzyme system and a pronounced elevation in the cyclic AMP concentration of the placenta. The presence of prostaglandin E₂ in the culture medium evoked a similar glycogenolytic effect in immature human placental villi including the increase in tissue cyclic AMP levels. These findings suggest a second messenger role of the prostaglandins in HCG action and results are discussed in light of the mechanism of action of HCG on the human placenta.

Original language	English (US)
Pages (from-to)	202-210
Number of pages	9
Journal	BBA - General Subjects
Volume	313
Issue number	1
DOIs	https://doi.org/10.1016/0304-4165(73)90201-8
State	Published - Jun 30 1973

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology

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10.1016/0304-4165(73)90201-8

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title = "Human chorionic gonadotropin-mediated glycogenolysis in human placental villi: A role of prostaglandins",

abstract = "The acute {"}in vitro{"} effects of human chorionic gonadotropin (HCG) and protaglandin E2 on human placental glycogen metabolism have been studied in immature placental villi in short-term culture. HCG elicited within 15 min of culture, an acute glycogenolytic response in placental tissue which included a decrease in placental glycogen, an activation of the glycogen phosphorylase enzyme system and a pronounced elevation in the cyclic AMP concentration of the placenta. The presence of prostaglandin E2 in the culture medium evoked a similar glycogenolytic effect in immature human placental villi including the increase in tissue cyclic AMP levels. These findings suggest a second messenger role of the prostaglandins in HCG action and results are discussed in light of the mechanism of action of HCG on the human placenta.",

author = "{M. Demers}, Laurence and Gabbe, {Steven G.} and Villee, {Claude A.} and Greep, {Roy O.}",

note = "Funding Information: The authors wish to acknowledge the excellent technical assistance of Miss Jean Greenbaum and the typing of Mrs Pauline Breen. The iodination of the 2'-0-succinyltyrosine methyl ester derivative of cyclic AMP used in these studies was performed by Dr T. Makino, to whom we are extremely grateful. The prostaglandins used in these studies were generously supplied by Dr John Pike, The Upjohn Co. The research was supported by National Institutes of Health Grant HD-03736, and The Ford Foundation.",

year = "1973",

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doi = "10.1016/0304-4165(73)90201-8",

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T2 - A role of prostaglandins

AU - M. Demers, Laurence

AU - Gabbe, Steven G.

AU - Villee, Claude A.

AU - Greep, Roy O.

N1 - Funding Information: The authors wish to acknowledge the excellent technical assistance of Miss Jean Greenbaum and the typing of Mrs Pauline Breen. The iodination of the 2'-0-succinyltyrosine methyl ester derivative of cyclic AMP used in these studies was performed by Dr T. Makino, to whom we are extremely grateful. The prostaglandins used in these studies were generously supplied by Dr John Pike, The Upjohn Co. The research was supported by National Institutes of Health Grant HD-03736, and The Ford Foundation.

PY - 1973/6/30

Y1 - 1973/6/30

N2 - The acute "in vitro" effects of human chorionic gonadotropin (HCG) and protaglandin E2 on human placental glycogen metabolism have been studied in immature placental villi in short-term culture. HCG elicited within 15 min of culture, an acute glycogenolytic response in placental tissue which included a decrease in placental glycogen, an activation of the glycogen phosphorylase enzyme system and a pronounced elevation in the cyclic AMP concentration of the placenta. The presence of prostaglandin E2 in the culture medium evoked a similar glycogenolytic effect in immature human placental villi including the increase in tissue cyclic AMP levels. These findings suggest a second messenger role of the prostaglandins in HCG action and results are discussed in light of the mechanism of action of HCG on the human placenta.

AB - The acute "in vitro" effects of human chorionic gonadotropin (HCG) and protaglandin E2 on human placental glycogen metabolism have been studied in immature placental villi in short-term culture. HCG elicited within 15 min of culture, an acute glycogenolytic response in placental tissue which included a decrease in placental glycogen, an activation of the glycogen phosphorylase enzyme system and a pronounced elevation in the cyclic AMP concentration of the placenta. The presence of prostaglandin E2 in the culture medium evoked a similar glycogenolytic effect in immature human placental villi including the increase in tissue cyclic AMP levels. These findings suggest a second messenger role of the prostaglandins in HCG action and results are discussed in light of the mechanism of action of HCG on the human placenta.

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Human chorionic gonadotropin-mediated glycogenolysis in human placental villi: A role of prostaglandins

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