Human diurnal preference and circadian rhythmicity are not associated with the CLOCK 3111C/T gene polymorphism

Anne Marie Chang, Alison M. Buch, Dayna S. Bradstreet, David J. Klements, Jeanne F. Duffy

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Genetic association studies of the CLOCK 3111C/T polymorphism and diurnal preference have yielded conflicting results since the first report that the 3111C allele was associated with eveningness. The goal of the present study was to investigate the association of this polymorphism with diurnal preference and circadian physiology in a group of 179 individuals, by comparing the frequency of the 3111C allele to diurnal preference, habitual sleep timing, circadian phase markers, and circadian period. We did not find a significant association between this allele and morningness/eveningness or any circadian marker.

Original languageEnglish (US)
Pages (from-to)276-279
Number of pages4
JournalJournal of Biological Rhythms
Volume26
Issue number3
DOIs
StatePublished - Jun 2011

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

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