Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR

David J. Vandenbergh; Antonio M. Persico; Anita L. Hawkins; Constance A. Griffin; Xiang Li; Ethylin Wang Jabs; George R. Uhl

doi:10.1016/S0888-7543(05)80138-7

Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR

David J. Vandenbergh, Antonio M. Persico, Anita L. Hawkins, Constance A. Griffin, Xiang Li, Ethylin Wang Jabs, George R. Uhl

Research output: Contribution to journal › Article › peer-review

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Abstract

The human dopamine transporter (DAT1) gene is localized to chromosome 5p15.3 by in situ hybridization and PCR amplification of rodent somatic cell hybrid DNA. Analysis of a 40-bp repeat in the 3′ untranslated region of the message revealed variable numbers of the repeat ranging from 3 to 11 copies. These results will aid in the investigation of a role for this gene in genetic disorders of the dopaminergic system in humans.

Original language	English (US)
Pages (from-to)	1104-1106
Number of pages	3
Journal	Genomics
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/S0888-7543(05)80138-7
State	Published - Dec 1992

All Science Journal Classification (ASJC) codes

Genetics

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10.1016/S0888-7543(05)80138-7

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title = "Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR",

abstract = "The human dopamine transporter (DAT1) gene is localized to chromosome 5p15.3 by in situ hybridization and PCR amplification of rodent somatic cell hybrid DNA. Analysis of a 40-bp repeat in the 3′ untranslated region of the message revealed variable numbers of the repeat ranging from 3 to 11 copies. These results will aid in the investigation of a role for this gene in genetic disorders of the dopaminergic system in humans.",

author = "Vandenbergh, {David J.} and Persico, {Antonio M.} and Hawkins, {Anita L.} and Griffin, {Constance A.} and Xiang Li and Jabs, {Ethylin Wang} and Uhl, {George R.}",

note = "Funding Information: for careful assistance with the manuscript, and the support from the intramural program of the National Institute of Drug Abuse and NIH Grants 5P01 GM1015-02 to E. W. Jabs and C. A. Griffin and DE10180 to E. W. Jabs.",

year = "1992",

month = dec,

doi = "10.1016/S0888-7543(05)80138-7",

language = "English (US)",

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T1 - Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR

AU - Vandenbergh, David J.

AU - Persico, Antonio M.

AU - Hawkins, Anita L.

AU - Griffin, Constance A.

AU - Li, Xiang

AU - Jabs, Ethylin Wang

AU - Uhl, George R.

N1 - Funding Information: for careful assistance with the manuscript, and the support from the intramural program of the National Institute of Drug Abuse and NIH Grants 5P01 GM1015-02 to E. W. Jabs and C. A. Griffin and DE10180 to E. W. Jabs.

PY - 1992/12

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AB - The human dopamine transporter (DAT1) gene is localized to chromosome 5p15.3 by in situ hybridization and PCR amplification of rodent somatic cell hybrid DNA. Analysis of a 40-bp repeat in the 3′ untranslated region of the message revealed variable numbers of the repeat ranging from 3 to 11 copies. These results will aid in the investigation of a role for this gene in genetic disorders of the dopaminergic system in humans.

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Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR

Abstract

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