Human gingiva-derived mesenchymal stem cells modulate monocytes/macrophages and alleviate atherosclerosis

Ximei Zhang, Feng Huang, Weixuan Li, Jun Long Dang, Jia Yuan, Julie Wang, Dong Lan Zeng, Can Xing Sun, Yan Ying Liu, Qian Ao, Hongmei Tan, Wenru Su, Xiaoxian Qian, Nancy Olsen, Song Guo Zheng

Research output: Contribution to journalArticle

Abstract

Atherosclerosis is the major cause of cardiovascular diseases. Current evidences indicate that inflammation is involved in the pathogenesis of atherosclerosis. Human gingiva-derived mesenchymal stem cells (GMSC) have shown anti-inflammatory and immunomodulatory effects on autoimmune and inflammatory diseases. However, the function of GMSC in controlling atherosclerosis is far from clear. The present study is aimed to elucidate the role of GMSC in atherosclerosis, examining the inhibition of GMSC on macrophage foam cell formation, and further determining whether GMSC could affect the polarization and activation of macrophages under different conditions. The results show that infusion of GMSC to AopE-/- mice significantly reduced the frequency of inflammatory monocytes/macrophages and decreased the plaque size and lipid deposition. Additionally, GMSC treatment markedly inhibited macrophage foam cell formation and reduced inflammatory macrophage activation, converting inflammatory macrophages to anti-inflammatory macrophages in vitro. Thus, our study has revealed a significant role of GMSC on modulating inflammatory monocytes/macrophages and alleviating atherosclerosis.

LanguageEnglish (US)
Article number878
JournalFrontiers in Immunology
Volume9
Issue numberAPR
DOIs
StatePublished - Apr 30 2018

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Gingiva
Mesenchymal Stromal Cells
Monocytes
Atherosclerosis
Macrophages
Foam Cells
Macrophage Activation
Anti-Inflammatory Agents
Autoimmune Diseases
Cardiovascular Diseases
Inflammation
Lipids

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Zhang, Ximei ; Huang, Feng ; Li, Weixuan ; Dang, Jun Long ; Yuan, Jia ; Wang, Julie ; Zeng, Dong Lan ; Sun, Can Xing ; Liu, Yan Ying ; Ao, Qian ; Tan, Hongmei ; Su, Wenru ; Qian, Xiaoxian ; Olsen, Nancy ; Zheng, Song Guo. / Human gingiva-derived mesenchymal stem cells modulate monocytes/macrophages and alleviate atherosclerosis. In: Frontiers in Immunology. 2018 ; Vol. 9, No. APR.
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title = "Human gingiva-derived mesenchymal stem cells modulate monocytes/macrophages and alleviate atherosclerosis",
abstract = "Atherosclerosis is the major cause of cardiovascular diseases. Current evidences indicate that inflammation is involved in the pathogenesis of atherosclerosis. Human gingiva-derived mesenchymal stem cells (GMSC) have shown anti-inflammatory and immunomodulatory effects on autoimmune and inflammatory diseases. However, the function of GMSC in controlling atherosclerosis is far from clear. The present study is aimed to elucidate the role of GMSC in atherosclerosis, examining the inhibition of GMSC on macrophage foam cell formation, and further determining whether GMSC could affect the polarization and activation of macrophages under different conditions. The results show that infusion of GMSC to AopE-/- mice significantly reduced the frequency of inflammatory monocytes/macrophages and decreased the plaque size and lipid deposition. Additionally, GMSC treatment markedly inhibited macrophage foam cell formation and reduced inflammatory macrophage activation, converting inflammatory macrophages to anti-inflammatory macrophages in vitro. Thus, our study has revealed a significant role of GMSC on modulating inflammatory monocytes/macrophages and alleviating atherosclerosis.",
author = "Ximei Zhang and Feng Huang and Weixuan Li and Dang, {Jun Long} and Jia Yuan and Julie Wang and Zeng, {Dong Lan} and Sun, {Can Xing} and Liu, {Yan Ying} and Qian Ao and Hongmei Tan and Wenru Su and Xiaoxian Qian and Nancy Olsen and Zheng, {Song Guo}",
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Zhang, X, Huang, F, Li, W, Dang, JL, Yuan, J, Wang, J, Zeng, DL, Sun, CX, Liu, YY, Ao, Q, Tan, H, Su, W, Qian, X, Olsen, N & Zheng, SG 2018, 'Human gingiva-derived mesenchymal stem cells modulate monocytes/macrophages and alleviate atherosclerosis' Frontiers in Immunology, vol. 9, no. APR, 878. https://doi.org/10.3389/fimmu.2018.00878

Human gingiva-derived mesenchymal stem cells modulate monocytes/macrophages and alleviate atherosclerosis. / Zhang, Ximei; Huang, Feng; Li, Weixuan; Dang, Jun Long; Yuan, Jia; Wang, Julie; Zeng, Dong Lan; Sun, Can Xing; Liu, Yan Ying; Ao, Qian; Tan, Hongmei; Su, Wenru; Qian, Xiaoxian; Olsen, Nancy; Zheng, Song Guo.

In: Frontiers in Immunology, Vol. 9, No. APR, 878, 30.04.2018.

Research output: Contribution to journalArticle

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AU - Zeng, Dong Lan

AU - Sun, Can Xing

AU - Liu, Yan Ying

AU - Ao, Qian

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AU - Su, Wenru

AU - Qian, Xiaoxian

AU - Olsen, Nancy

AU - Zheng, Song Guo

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N2 - Atherosclerosis is the major cause of cardiovascular diseases. Current evidences indicate that inflammation is involved in the pathogenesis of atherosclerosis. Human gingiva-derived mesenchymal stem cells (GMSC) have shown anti-inflammatory and immunomodulatory effects on autoimmune and inflammatory diseases. However, the function of GMSC in controlling atherosclerosis is far from clear. The present study is aimed to elucidate the role of GMSC in atherosclerosis, examining the inhibition of GMSC on macrophage foam cell formation, and further determining whether GMSC could affect the polarization and activation of macrophages under different conditions. The results show that infusion of GMSC to AopE-/- mice significantly reduced the frequency of inflammatory monocytes/macrophages and decreased the plaque size and lipid deposition. Additionally, GMSC treatment markedly inhibited macrophage foam cell formation and reduced inflammatory macrophage activation, converting inflammatory macrophages to anti-inflammatory macrophages in vitro. Thus, our study has revealed a significant role of GMSC on modulating inflammatory monocytes/macrophages and alleviating atherosclerosis.

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