Human herpesvirus 6: Infection and disease following autologous and allogeneic bone marrow transplantation

Madhavi P. Kadakia, Witold Rybka, John A. Stewart, Joanne L. Patton, Felicia R. Stamey, Magdy Elsawy, Philip E. Pellett, John A. Armstrong

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Abstract

Human herpesvirus 6 activity (HHV-6) was studied in 15 allogeneic and 11 autologous marrow transplantation patients. After transplantation, HHV-6 was isolated from the peripheral blood mononuclear cells of 12 of 26 patients (6 allogeneic and 6 autologous). All isolates were variant B. Eleven of 26 and 12 of 19 patients showed salivary shedding of HHV-6 DNA before and after transplantation, respectively. The antibody titer increased in 7 of 26 patients. Thus, 23 of 26 patients showed evidence of active HHV-6 infection either by virus isolation, salivary shedding, or increases in antibody titers. The fraction of saliva specimens positive in 19 patients was negatively associated with their antibody titers (P = .005). The proportion of cultures positive increased after transplantation (P = .007). Sinusitis was associated with HHV-6 isolation in autologous recipients (P = .002). In allogeneic patients, active human cytomegalovirus infection was associated with HHV-6 isolation (P = .04). No association was observed between HHV-6 infection and GVHD, pneumonia, delay in engraftment, or marrow suppression. Of the 120 clinical events analyzed in 26 patients, HHV-6 was defined as a probable cause of 16 events in 9 patients based on the propinquity of HHV-6 activity and the clinical event plus the absence of other identified causes of the event.

Original languageEnglish (US)
Pages (from-to)5341-5354
Number of pages14
JournalBlood
Volume87
Issue number12
StatePublished - Jun 15 1996

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Kadakia, M. P., Rybka, W., Stewart, J. A., Patton, J. L., Stamey, F. R., Elsawy, M., Pellett, P. E., & Armstrong, J. A. (1996). Human herpesvirus 6: Infection and disease following autologous and allogeneic bone marrow transplantation. Blood, 87(12), 5341-5354.