TY - JOUR
T1 - Human ovarian theca cells in culture
AU - Wickenheisser, Jessica K.
AU - Nelson-DeGrave, Velen L.
AU - McAllister, Janette
N1 - Funding Information:
This work was supported by NIH grants HD33852 and HD34449. We thank Margaret Hinshelwood and Karen Hendricks for their helpful comments and editorial assistance.
PY - 2006/3
Y1 - 2006/3
N2 - Elucidating the regulation of androgen biosynthesis in ovarian theca cells is not only important for determining the mechanisms of regulation of estrogen biosynthesis throughout the menstrual cycle, but is also essential for understanding the pathogenesis of excess androgen biosynthesis and polycystic ovary syndrome (PCOS). Human theca cells in primary and long-term culture have provided model systems for examining theca cell differentiation as well as the mechanisms underlying basal and cAMP-regulated steroid biosynthesis at both the transcriptional and post-transcriptional level in normal and PCOS ovaries. Results of these studies are expected to lead to the identification of novel targets for clinical treatment of infertility and PCOS.
AB - Elucidating the regulation of androgen biosynthesis in ovarian theca cells is not only important for determining the mechanisms of regulation of estrogen biosynthesis throughout the menstrual cycle, but is also essential for understanding the pathogenesis of excess androgen biosynthesis and polycystic ovary syndrome (PCOS). Human theca cells in primary and long-term culture have provided model systems for examining theca cell differentiation as well as the mechanisms underlying basal and cAMP-regulated steroid biosynthesis at both the transcriptional and post-transcriptional level in normal and PCOS ovaries. Results of these studies are expected to lead to the identification of novel targets for clinical treatment of infertility and PCOS.
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U2 - 10.1016/j.tem.2006.01.003
DO - 10.1016/j.tem.2006.01.003
M3 - Review article
C2 - 16460956
AN - SCOPUS:33644501433
VL - 17
SP - 65
EP - 71
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
SN - 1043-2760
IS - 2
ER -