Human polyomavirus JC virus genome

R. J. Frisque, G. L. Bream, M. T. Cannella

Research output: Contribution to journalArticle

515 Citations (Scopus)

Abstract

The complete DNA sequence of the human JC virus, which was found to consist of 5,130 nucleotide pairs, is presented. The amino acid sequence of six proteins could be deduced: the early, nonstructural proteins, large T and small t antigens; the late capsid proteins, VP1, VP2, and VP3; and the agnogene product encoded within the late leader sequence, called the agnoprotein in simian virus 40. The extent of homology between JC virus DNA and the genomes of simian virus 40 (69%) and BK virus (75%) confirmed the close evolutionary relationship of these three polyomaviruses. The sequences showing the greatest divergence in these viral DNAs occurred within the tandem repeats located to the late side of the replication origins.

Original languageEnglish (US)
Pages (from-to)458-469
Number of pages12
JournalJournal of Virology
Volume51
Issue number2
StatePublished - 1984

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JC polyomavirus
Simian virus 40
JC Virus
Polyomaviridae
Genome
BK Virus
replication origin
Polyomavirus
Tandem Repeat Sequences
Replication Origin
genome
tandem repeat sequences
Viral Tumor Antigens
Viral DNA
Capsid Proteins
DNA
coat proteins
Amino Acid Sequence
Proteins
amino acid sequences

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Frisque, R. J., Bream, G. L., & Cannella, M. T. (1984). Human polyomavirus JC virus genome. Journal of Virology, 51(2), 458-469.
Frisque, R. J. ; Bream, G. L. ; Cannella, M. T. / Human polyomavirus JC virus genome. In: Journal of Virology. 1984 ; Vol. 51, No. 2. pp. 458-469.
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Frisque, RJ, Bream, GL & Cannella, MT 1984, 'Human polyomavirus JC virus genome', Journal of Virology, vol. 51, no. 2, pp. 458-469.

Human polyomavirus JC virus genome. / Frisque, R. J.; Bream, G. L.; Cannella, M. T.

In: Journal of Virology, Vol. 51, No. 2, 1984, p. 458-469.

Research output: Contribution to journalArticle

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Frisque RJ, Bream GL, Cannella MT. Human polyomavirus JC virus genome. Journal of Virology. 1984;51(2):458-469.