Human prion protein cDNA: Molecular cloning, chromosomal mapping, and biological implications

Y. U.Cheng J. Liao, Roger V. Lebo, Gary A. Clawson, Edward A. Smuckler

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

A human complementary DNA whose protein product is considered to be the major component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, and Gerstmann-Straussler syndrome has been identified and characterized. The extensive homology of this gene sequence to the hamster PrP 27- to 30-kilodalton prion protein complementary DNA clone, and its existence as a single copy in the human genome, leads to the conclusion that this is the human prion gene. This human prion gene has been mapped to human chromosome 20, negating a direct link between the prion protein and Down's syndrome or the amyloid of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)364-367
Number of pages4
JournalScience
Volume233
Issue number4761
DOIs
StatePublished - Jan 1 1986

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Molecular Cloning
Complementary DNA
Prions
PrP 27-30 Protein
Gerstmann-Straussler-Scheinker Disease
Kuru
Chromosomes, Human, Pair 20
Genes
Creutzfeldt-Jakob Syndrome
Human Chromosomes
Human Genome
Sequence Homology
Down Syndrome
Amyloid
Cricetinae
Alzheimer Disease
Clone Cells
Prion Proteins
Proteins

All Science Journal Classification (ASJC) codes

  • General

Cite this

Liao, Y. U.Cheng J. ; Lebo, Roger V. ; Clawson, Gary A. ; Smuckler, Edward A. / Human prion protein cDNA : Molecular cloning, chromosomal mapping, and biological implications. In: Science. 1986 ; Vol. 233, No. 4761. pp. 364-367.
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Human prion protein cDNA : Molecular cloning, chromosomal mapping, and biological implications. / Liao, Y. U.Cheng J.; Lebo, Roger V.; Clawson, Gary A.; Smuckler, Edward A.

In: Science, Vol. 233, No. 4761, 01.01.1986, p. 364-367.

Research output: Contribution to journalArticle

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