Human prion protein cDNA: Molecular cloning, chromosomal mapping, and biological implications

Y. U.Cheng J. Liao, Roger V. Lebo, Gary A. Clawson, Edward A. Smuckler

Research output: Contribution to journalArticlepeer-review

104 Scopus citations

Abstract

A human complementary DNA whose protein product is considered to be the major component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, and Gerstmann-Straussler syndrome has been identified and characterized. The extensive homology of this gene sequence to the hamster PrP 27- to 30-kilodalton prion protein complementary DNA clone, and its existence as a single copy in the human genome, leads to the conclusion that this is the human prion gene. This human prion gene has been mapped to human chromosome 20, negating a direct link between the prion protein and Down's syndrome or the amyloid of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)364-367
Number of pages4
JournalScience
Volume233
Issue number4761
DOIs
StatePublished - 1986

All Science Journal Classification (ASJC) codes

  • General

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