Human variants of O6-alkylguanine-DNA alkyltransferase

Anthony Pegg, Qingming Fang, Natalia A. Loktionova

Research output: Contribution to journalReview article

51 Citations (Scopus)

Abstract

This article summarizes the current understanding of known variant forms of the MGMT gene that encode an altered protein. Epidemiological studies have been carried out to test whether these alterations are associated with altered cancer risk. Laboratory studies using recombinant proteins and cells expressing the known variants have investigated the possible effects of these sequence alterations on the ability of the encoded O6-alkylguanine-DNA alkyltransferase protein to protect cells from alkylation damage and to respond to therapeutic inactivators currently undergoing trials for cancer chemotherapy.

Original languageEnglish (US)
Pages (from-to)1071-1078
Number of pages8
JournalDNA Repair
Volume6
Issue number8
DOIs
StatePublished - Aug 1 2007

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Chemotherapy
Alkylation
Recombinant Proteins
Epidemiologic Studies
Neoplasms
Proteins
Genes
Cells
Drug Therapy
DNA alkyltransferase
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Pegg, Anthony ; Fang, Qingming ; Loktionova, Natalia A. / Human variants of O6-alkylguanine-DNA alkyltransferase. In: DNA Repair. 2007 ; Vol. 6, No. 8. pp. 1071-1078.
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Human variants of O6-alkylguanine-DNA alkyltransferase. / Pegg, Anthony; Fang, Qingming; Loktionova, Natalia A.

In: DNA Repair, Vol. 6, No. 8, 01.08.2007, p. 1071-1078.

Research output: Contribution to journalReview article

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