Humoral and cell-mediated immunity to the intracellular pathogen Francisella tularensis

Girish Soorapp Kirimanjeswara, Sofia Olmos, Chandra S. Bakshi, Dennis W. Metzger

Research output: Contribution to journalReview article

81 Citations (Scopus)

Abstract

Francisella tularensis can cause fatal respiratory tularemia in humans and animals and is increasingly being isolated in the United States and several European countries. The correlates of protective immunity against this intracellular bacterium are not known, and currently there are no licensed vaccines available for human use. Cell-mediated immunity has long been believed to be critical for protection, and the importance of humoral immunity is also now recognized. Furthermore, synergy between antibodies, T cell-derived cytokines, and phagocytes appears to be critical to achieve sterilizing immunity against F. tularensis. Thus, novel vaccine approaches should be designed to induce robust antibody and cell-mediated immune responses to this pathogen.

Original languageEnglish (US)
Pages (from-to)244-255
Number of pages12
JournalImmunological Reviews
Volume225
Issue number1
DOIs
StatePublished - Oct 1 2008

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Francisella tularensis
Cellular Immunity
Immunity
Vaccines
Tularemia
Antibodies
Phagocytes
Humoral Immunity
Cytokines
Bacteria
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Kirimanjeswara, Girish Soorapp ; Olmos, Sofia ; Bakshi, Chandra S. ; Metzger, Dennis W. / Humoral and cell-mediated immunity to the intracellular pathogen Francisella tularensis. In: Immunological Reviews. 2008 ; Vol. 225, No. 1. pp. 244-255.
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Humoral and cell-mediated immunity to the intracellular pathogen Francisella tularensis. / Kirimanjeswara, Girish Soorapp; Olmos, Sofia; Bakshi, Chandra S.; Metzger, Dennis W.

In: Immunological Reviews, Vol. 225, No. 1, 01.10.2008, p. 244-255.

Research output: Contribution to journalReview article

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