Humors and Diarrhea

William Terranova, Sherwin H. Malt, Laurence Demers

Research output: Contribution to journalLetter

Abstract

To the Editor: Luderer et al. state, in their article entitled “Elevated Prostaglandin E in Idiopathic Pseudo-obstruction” (N Engl J Med 295:1179, 1976), “Prostaglandins have been implicated in the pathogenesis of…diarrhea syndromes, including cholera….” They provide no documentation for this statement. Early in this decade prostaglandins were shown to increase mucosal adenyl cyclase in the intestine1 and to stimulate small-bowel water and electrolyte secretion.2 When it was shown that cholera enterotoxin also stimulates adenyl cyclase, thereby increasing the concentration of cyclic AMP and stimulating small-bowel water and electrolyte secretion,13 it was suggested that the effects of the toxin might.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Volume296
Issue number6
DOIs
StatePublished - Feb 10 1977

Fingerprint

Wit and Humor
Adenylyl Cyclases
Electrolytes
Prostaglandins
Diarrhea
Water
Cholera
Prostaglandins E
Documentation
Cyclic AMP
Vibrio cholerae stN protein

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Terranova, William ; Malt, Sherwin H. ; Demers, Laurence. / Humors and Diarrhea. In: New England Journal of Medicine. 1977 ; Vol. 296, No. 6.
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Terranova, W, Malt, SH & Demers, L 1977, 'Humors and Diarrhea', New England Journal of Medicine, vol. 296, no. 6. https://doi.org/10.1056/NEJM197702102960619

Humors and Diarrhea. / Terranova, William; Malt, Sherwin H.; Demers, Laurence.

In: New England Journal of Medicine, Vol. 296, No. 6, 10.02.1977.

Research output: Contribution to journalLetter

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AU - Malt, Sherwin H.

AU - Demers, Laurence

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