Huntingtin interacting protein 14 is an oncogenic human protein: Palmitoyl acyltransferase

Charles E. Ducker, Erin M. Stettler, Kevin J. French, John J. Upson, Charles D. Smith

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

Protein palmitoyltransferases (PATs) represent an exciting new target for anticancer drug design due to their pivotal roles in the subcellular localization of a number of oncogenes. We show that the Huntingtin interacting protein 14 (HIP14) is a PAT with a preference for the farnesyl-dependent palmitoylation motif found in H- and N-RAS. Characterization of HIP14 in mouse cells has revealed that it has the ability to induce colony formation in cell culture, anchorage-independent growth, and tumors in mice. Activity of the enzyme and its ability to transform cells is dependent on critical residues in the active site of the enzyme.

Original languageEnglish (US)
Pages (from-to)9230-9237
Number of pages8
JournalOncogene
Volume23
Issue number57
DOIs
StatePublished - Dec 9 2004

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

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