Previous analytical, numerical, and experimental studies have been conducted to assess the behavior of semi-rigid partial-strength beam-column subassemblies and the results showed desirable behavior. However, realistic evaluation of semi-rigid steel frames requires a system-level examination to allow for investigating the effect of local behavior of the connection on the global response of the structural system. Most of previously conducted studies on system-level assessment utilized finite element analysis with line elements representing the beams and columns and rotational springs representing the connections using an idealized moment-rotation relationships. One of the shortcomings of this approach, in addition to idealizing the momentrotation relationships, is that the interaction between the beam and column flanges and the angles comprising the connection is not accounted for. This paper discusses an advanced hybrid simulation application for the seismic assessment of steel frames with top and seat-angle with double web-angle (TSADWA) connections using advanced experimental setup and a new detailed multi-resolution finite element model. The findings of the simulations with focus on connection behavior and frame response is highlighted. The results provide valuable insight to engineers into the expected behavior of steel frames with TSADWA connections under moderate-to-high seismic demands.