Hydrochlorothiazide‐Induced 131I Excretion Facilitated by Salt and Water

KARL H. BEYER, David Fehr, R. THOMAS GELARDEN, WILLIAM J. WHITE, C. MAX LANG, ELLIOT S. VESELL

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Abstract: Salt intake is restricted under clinical conditions for which thiazide diuretics are customarily used. Dietary iodide intake offsets any effect of thiazide on iodide loss. However, our correlation coefficients relating Na+ to Cl to l excretion indicate that as thiazide administration or sodium chloride intake increases renal Na+ and Cl excretion, l reabsorption by the nephron coordinately decreases. Increased sodium chloride and water intake by the dog doubled lexcretion rates. Hydrochlorothiazide increased the sodium chloride and water enhanced lexcretion rate as much as eight‐fold. Without added NaCl, hydrochlorothiazide increased the excretion rate of 131I by three‐ to eightfold, acutely. Within five to seven days after 131I oral administration, hydrochlorothiazide (1 or 2 mg/kg twice daily) doubled the rate of 131I disappearance from plasma, reduced the fecal output of 131I, and increased its rate of renal excretion. When hydrochlorothiazide was administered, as much 131I was excreted in the first 24 hours as occurred in 48 hours when sodium chloride and water were given without hydrochlorothiazide. Thiazide administration in customary clinical dosage twice a day with substantial sodium chloride and water for the first two days after exposure to 131I, should therefore facilitate the safe excretion of 131I. This accelerated removal of 131I might be enhanced even more if thyroid uptake of 131I is blocked by administration of potassium iodide, as judged by the greater 131I recovery from thyroidectomized dogs. 1981 American College of Clinical Pharmacology

Original languageEnglish (US)
Pages (from-to)201-212
Number of pages12
JournalThe Journal of Clinical Pharmacology
Volume21
Issue number5-6
DOIs
StatePublished - Jan 1 1981

Fingerprint

Hydrochlorothiazide
Sodium Chloride
Thiazides
Salts
Water
Iodides
Dogs
Sodium Chloride Symporter Inhibitors
Potassium Iodide
Clinical Pharmacology
Nephrons
Drinking
Oral Administration
Thyroid Gland
Kidney

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

BEYER, KARL. H., Fehr, D., GELARDEN, R. THOMAS., WHITE, WILLIAM. J., LANG, C. MAX., & VESELL, ELLIOT. S. (1981). Hydrochlorothiazide‐Induced 131I Excretion Facilitated by Salt and Water. The Journal of Clinical Pharmacology, 21(5-6), 201-212. https://doi.org/10.1002/j.1552-4604.1981.tb02549.x
BEYER, KARL H. ; Fehr, David ; GELARDEN, R. THOMAS ; WHITE, WILLIAM J. ; LANG, C. MAX ; VESELL, ELLIOT S. / Hydrochlorothiazide‐Induced 131I Excretion Facilitated by Salt and Water. In: The Journal of Clinical Pharmacology. 1981 ; Vol. 21, No. 5-6. pp. 201-212.
@article{70b577cce49a439ab4f2ac512c61d328,
title = "Hydrochlorothiazide‐Induced 131I Excretion Facilitated by Salt and Water",
abstract = "Abstract: Salt intake is restricted under clinical conditions for which thiazide diuretics are customarily used. Dietary iodide intake offsets any effect of thiazide on iodide loss. However, our correlation coefficients relating Na+ to Cl− to l− excretion indicate that as thiazide administration or sodium chloride intake increases renal Na+ and Cl− excretion, l− reabsorption by the nephron coordinately decreases. Increased sodium chloride and water intake by the dog doubled l−excretion rates. Hydrochlorothiazide increased the sodium chloride and water enhanced l−excretion rate as much as eight‐fold. Without added NaCl, hydrochlorothiazide increased the excretion rate of 131I by three‐ to eightfold, acutely. Within five to seven days after 131I oral administration, hydrochlorothiazide (1 or 2 mg/kg twice daily) doubled the rate of 131I disappearance from plasma, reduced the fecal output of 131I, and increased its rate of renal excretion. When hydrochlorothiazide was administered, as much 131I was excreted in the first 24 hours as occurred in 48 hours when sodium chloride and water were given without hydrochlorothiazide. Thiazide administration in customary clinical dosage twice a day with substantial sodium chloride and water for the first two days after exposure to 131I, should therefore facilitate the safe excretion of 131I. This accelerated removal of 131I might be enhanced even more if thyroid uptake of 131I is blocked by administration of potassium iodide, as judged by the greater 131I recovery from thyroidectomized dogs. 1981 American College of Clinical Pharmacology",
author = "BEYER, {KARL H.} and David Fehr and GELARDEN, {R. THOMAS} and WHITE, {WILLIAM J.} and LANG, {C. MAX} and VESELL, {ELLIOT S.}",
year = "1981",
month = "1",
day = "1",
doi = "10.1002/j.1552-4604.1981.tb02549.x",
language = "English (US)",
volume = "21",
pages = "201--212",
journal = "Journal of Clinical Pharmacology",
issn = "0091-2700",
publisher = "SAGE Publications Inc.",
number = "5-6",

}

BEYER, KARLH, Fehr, D, GELARDEN, RTHOMAS, WHITE, WILLIAMJ, LANG, CMAX & VESELL, ELLIOTS 1981, 'Hydrochlorothiazide‐Induced 131I Excretion Facilitated by Salt and Water', The Journal of Clinical Pharmacology, vol. 21, no. 5-6, pp. 201-212. https://doi.org/10.1002/j.1552-4604.1981.tb02549.x

Hydrochlorothiazide‐Induced 131I Excretion Facilitated by Salt and Water. / BEYER, KARL H.; Fehr, David; GELARDEN, R. THOMAS; WHITE, WILLIAM J.; LANG, C. MAX; VESELL, ELLIOT S.

In: The Journal of Clinical Pharmacology, Vol. 21, No. 5-6, 01.01.1981, p. 201-212.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hydrochlorothiazide‐Induced 131I Excretion Facilitated by Salt and Water

AU - BEYER, KARL H.

AU - Fehr, David

AU - GELARDEN, R. THOMAS

AU - WHITE, WILLIAM J.

AU - LANG, C. MAX

AU - VESELL, ELLIOT S.

PY - 1981/1/1

Y1 - 1981/1/1

N2 - Abstract: Salt intake is restricted under clinical conditions for which thiazide diuretics are customarily used. Dietary iodide intake offsets any effect of thiazide on iodide loss. However, our correlation coefficients relating Na+ to Cl− to l− excretion indicate that as thiazide administration or sodium chloride intake increases renal Na+ and Cl− excretion, l− reabsorption by the nephron coordinately decreases. Increased sodium chloride and water intake by the dog doubled l−excretion rates. Hydrochlorothiazide increased the sodium chloride and water enhanced l−excretion rate as much as eight‐fold. Without added NaCl, hydrochlorothiazide increased the excretion rate of 131I by three‐ to eightfold, acutely. Within five to seven days after 131I oral administration, hydrochlorothiazide (1 or 2 mg/kg twice daily) doubled the rate of 131I disappearance from plasma, reduced the fecal output of 131I, and increased its rate of renal excretion. When hydrochlorothiazide was administered, as much 131I was excreted in the first 24 hours as occurred in 48 hours when sodium chloride and water were given without hydrochlorothiazide. Thiazide administration in customary clinical dosage twice a day with substantial sodium chloride and water for the first two days after exposure to 131I, should therefore facilitate the safe excretion of 131I. This accelerated removal of 131I might be enhanced even more if thyroid uptake of 131I is blocked by administration of potassium iodide, as judged by the greater 131I recovery from thyroidectomized dogs. 1981 American College of Clinical Pharmacology

AB - Abstract: Salt intake is restricted under clinical conditions for which thiazide diuretics are customarily used. Dietary iodide intake offsets any effect of thiazide on iodide loss. However, our correlation coefficients relating Na+ to Cl− to l− excretion indicate that as thiazide administration or sodium chloride intake increases renal Na+ and Cl− excretion, l− reabsorption by the nephron coordinately decreases. Increased sodium chloride and water intake by the dog doubled l−excretion rates. Hydrochlorothiazide increased the sodium chloride and water enhanced l−excretion rate as much as eight‐fold. Without added NaCl, hydrochlorothiazide increased the excretion rate of 131I by three‐ to eightfold, acutely. Within five to seven days after 131I oral administration, hydrochlorothiazide (1 or 2 mg/kg twice daily) doubled the rate of 131I disappearance from plasma, reduced the fecal output of 131I, and increased its rate of renal excretion. When hydrochlorothiazide was administered, as much 131I was excreted in the first 24 hours as occurred in 48 hours when sodium chloride and water were given without hydrochlorothiazide. Thiazide administration in customary clinical dosage twice a day with substantial sodium chloride and water for the first two days after exposure to 131I, should therefore facilitate the safe excretion of 131I. This accelerated removal of 131I might be enhanced even more if thyroid uptake of 131I is blocked by administration of potassium iodide, as judged by the greater 131I recovery from thyroidectomized dogs. 1981 American College of Clinical Pharmacology

UR - http://www.scopus.com/inward/record.url?scp=0019390329&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019390329&partnerID=8YFLogxK

U2 - 10.1002/j.1552-4604.1981.tb02549.x

DO - 10.1002/j.1552-4604.1981.tb02549.x

M3 - Article

C2 - 7263913

AN - SCOPUS:0019390329

VL - 21

SP - 201

EP - 212

JO - Journal of Clinical Pharmacology

JF - Journal of Clinical Pharmacology

SN - 0091-2700

IS - 5-6

ER -