Hydrogels based on schiff base formation between an amino-containing polyphosphazene and aldehyde functionalized-dextrans

Nicole L. Morozowich, Jessica L. Nichol, Harry R. Allcock

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Hydrogels generated by the interaction of two different water-soluble polymers offer access to a new group of soft materials. A prototype amino-functionalized polyphosphazene with both tyramine and ferulic acid-based side groups was coupled to aldehyde functionalized-dextrans to form hydrogels crosslinked via Schiff base chemistry. Synthesis of the polyphosphazene was accomplished by macromolecular substitution and protection-deprotection chemistry, with characterization by 1H NMR, 31P NMR, solid state 13C NMR, and DSC techniques. Combination of the aqueous polyphosphazene and aldehyde functionalized-dextran solutions at room temperature caused gelation with different gelation times and crosslink densities dependent on the aldehyde content of the dextran. The hydrogel properties were evaluated using rheology, thermal characterization, and cryo-microscopy.

Original languageEnglish (US)
Pages (from-to)2984-2991
Number of pages8
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume54
Issue number18
DOIs
StatePublished - Sep 15 2016

All Science Journal Classification (ASJC) codes

  • Materials Chemistry
  • Polymers and Plastics
  • Organic Chemistry

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