TY - JOUR
T1 - Hydrogels based on schiff base formation between an amino-containing polyphosphazene and aldehyde functionalized-dextrans
AU - Morozowich, Nicole L.
AU - Nichol, Jessica L.
AU - Allcock, Harry R.
PY - 2016/9/15
Y1 - 2016/9/15
N2 - Hydrogels generated by the interaction of two different water-soluble polymers offer access to a new group of soft materials. A prototype amino-functionalized polyphosphazene with both tyramine and ferulic acid-based side groups was coupled to aldehyde functionalized-dextrans to form hydrogels crosslinked via Schiff base chemistry. Synthesis of the polyphosphazene was accomplished by macromolecular substitution and protection-deprotection chemistry, with characterization by 1H NMR, 31P NMR, solid state 13C NMR, and DSC techniques. Combination of the aqueous polyphosphazene and aldehyde functionalized-dextran solutions at room temperature caused gelation with different gelation times and crosslink densities dependent on the aldehyde content of the dextran. The hydrogel properties were evaluated using rheology, thermal characterization, and cryo-microscopy.
AB - Hydrogels generated by the interaction of two different water-soluble polymers offer access to a new group of soft materials. A prototype amino-functionalized polyphosphazene with both tyramine and ferulic acid-based side groups was coupled to aldehyde functionalized-dextrans to form hydrogels crosslinked via Schiff base chemistry. Synthesis of the polyphosphazene was accomplished by macromolecular substitution and protection-deprotection chemistry, with characterization by 1H NMR, 31P NMR, solid state 13C NMR, and DSC techniques. Combination of the aqueous polyphosphazene and aldehyde functionalized-dextran solutions at room temperature caused gelation with different gelation times and crosslink densities dependent on the aldehyde content of the dextran. The hydrogel properties were evaluated using rheology, thermal characterization, and cryo-microscopy.
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U2 - 10.1002/pola.28184
DO - 10.1002/pola.28184
M3 - Article
AN - SCOPUS:84977106700
VL - 54
SP - 2984
EP - 2991
JO - Journal of Polymer Science, Part A: Polymer Chemistry
JF - Journal of Polymer Science, Part A: Polymer Chemistry
SN - 0887-624X
IS - 18
ER -