Hyperconnectivity is a fundamental response to neurological disruption

Frank Gerard Hillary, Cristina A. Roman, Umesh Venkatesan, Sarah Rajtmajer, Ricardo Bajo, Nazareth D. Castellanos

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Objective: In the cognitive and clinical neurosciences, the past decade has been marked by dramatic growth in a literature examining brain "connectivity" using noninvasive methods. We offer a critical review of the blood oxygen level dependent functional MRI (BOLD fMRI) literature examining neural connectivity changes in neurological disorders with focus on brain injury and dementia. The goal is to demonstrate that there are identifiable shifts in local and large-scale network connectivity that can be predicted by the degree of pathology. We anticipate that the most common network response to neurological insult is hyperconnectivity but that this response depends upon demand and resource availability. Method: To examine this hypothesis, we initially reviewed the results from 1,426 studies examining functional brain connectivity in individuals diagnosed with multiple sclerosis, traumatic brain injury, mild cognitive impairment, and Alzheimer's disease. Based upon inclusionary criteria, 126 studies were included for detailed analysis. Results: Results from 126 studies examining local and whole brain connectivity demonstrated increased connectivity in traumatic brain injury and multiple sclerosis. This finding is juxtaposed with findings in mild cognitive impairment and Alzheimer's disease where there is a shift to diminished connectivity as degeneration progresses. Conclusion: This summary of the functional imaging literature using fMRI methods reveals that hyperconnectivity is a common response to neurological disruption and that it may be differentially observable across brain regions. We discuss the factors contributing to both hyper- and hypoconnectivity results after neurological disruption and the implications these findings have for network plasticity.

Original languageEnglish (US)
Pages (from-to)59-75
Number of pages17
JournalNeuropsychology
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2015

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Brain
Multiple Sclerosis
Alzheimer Disease
Magnetic Resonance Imaging
Nervous System Diseases
Brain Injuries
Dementia
Pathology
Oxygen
Growth
Cognitive Dysfunction
Traumatic Brain Injury
Cognitive Neuroscience

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology

Cite this

Hillary, Frank Gerard ; Roman, Cristina A. ; Venkatesan, Umesh ; Rajtmajer, Sarah ; Bajo, Ricardo ; Castellanos, Nazareth D. / Hyperconnectivity is a fundamental response to neurological disruption. In: Neuropsychology. 2015 ; Vol. 29, No. 1. pp. 59-75.
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Hyperconnectivity is a fundamental response to neurological disruption. / Hillary, Frank Gerard; Roman, Cristina A.; Venkatesan, Umesh; Rajtmajer, Sarah; Bajo, Ricardo; Castellanos, Nazareth D.

In: Neuropsychology, Vol. 29, No. 1, 01.01.2015, p. 59-75.

Research output: Contribution to journalArticle

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