Hypersensitivity pneumonitis

Correlation of cellular and immunologic changes with clinical phases of disease

H. Y. Reynolds

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Many airborne organic antigens in the form of fungal spores and thermophilic bacteria or dander and aerolized proteins can cause hypersensitivity pneumonitis after repeated inhalational exposure. Although a syndrome of acute illness often occurs, many people who are exposed and become sensitized can remain asymptomatic. However, immunologic evidence from an analysis of cells and antibodies obtained by bronchoalveolar lavage from asymptomatic subjects may indicate an ongoing alveolitis. With chronic illness, which has many characteristics of an interstitial fibrotic pneumonitis, a lymphocytic alveolitis and granulomatous reaction develop in the lungs. This review emphasizes the immunological changes in the lungs that occur at different phases of hypersensitivity pneumonitis and contribute to current concepts about pathogenetic mechanisms.

Original languageEnglish (US)
JournalLung
Volume169
Issue numberSUPPL.
StatePublished - 1991

Fingerprint

Extrinsic Allergic Alveolitis
Dander
Lung
Fungal Spores
Interstitial Lung Diseases
Bronchoalveolar Lavage
Chronic Disease
Bacteria
Antigens
Antibodies
Proteins

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

@article{3a9ac972f539430790224525193d0c22,
title = "Hypersensitivity pneumonitis: Correlation of cellular and immunologic changes with clinical phases of disease",
abstract = "Many airborne organic antigens in the form of fungal spores and thermophilic bacteria or dander and aerolized proteins can cause hypersensitivity pneumonitis after repeated inhalational exposure. Although a syndrome of acute illness often occurs, many people who are exposed and become sensitized can remain asymptomatic. However, immunologic evidence from an analysis of cells and antibodies obtained by bronchoalveolar lavage from asymptomatic subjects may indicate an ongoing alveolitis. With chronic illness, which has many characteristics of an interstitial fibrotic pneumonitis, a lymphocytic alveolitis and granulomatous reaction develop in the lungs. This review emphasizes the immunological changes in the lungs that occur at different phases of hypersensitivity pneumonitis and contribute to current concepts about pathogenetic mechanisms.",
author = "Reynolds, {H. Y.}",
year = "1991",
language = "English (US)",
volume = "169",
journal = "Lung",
issn = "0341-2040",
publisher = "Springer New York",
number = "SUPPL.",

}

Hypersensitivity pneumonitis : Correlation of cellular and immunologic changes with clinical phases of disease. / Reynolds, H. Y.

In: Lung, Vol. 169, No. SUPPL., 1991.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Hypersensitivity pneumonitis

T2 - Correlation of cellular and immunologic changes with clinical phases of disease

AU - Reynolds, H. Y.

PY - 1991

Y1 - 1991

N2 - Many airborne organic antigens in the form of fungal spores and thermophilic bacteria or dander and aerolized proteins can cause hypersensitivity pneumonitis after repeated inhalational exposure. Although a syndrome of acute illness often occurs, many people who are exposed and become sensitized can remain asymptomatic. However, immunologic evidence from an analysis of cells and antibodies obtained by bronchoalveolar lavage from asymptomatic subjects may indicate an ongoing alveolitis. With chronic illness, which has many characteristics of an interstitial fibrotic pneumonitis, a lymphocytic alveolitis and granulomatous reaction develop in the lungs. This review emphasizes the immunological changes in the lungs that occur at different phases of hypersensitivity pneumonitis and contribute to current concepts about pathogenetic mechanisms.

AB - Many airborne organic antigens in the form of fungal spores and thermophilic bacteria or dander and aerolized proteins can cause hypersensitivity pneumonitis after repeated inhalational exposure. Although a syndrome of acute illness often occurs, many people who are exposed and become sensitized can remain asymptomatic. However, immunologic evidence from an analysis of cells and antibodies obtained by bronchoalveolar lavage from asymptomatic subjects may indicate an ongoing alveolitis. With chronic illness, which has many characteristics of an interstitial fibrotic pneumonitis, a lymphocytic alveolitis and granulomatous reaction develop in the lungs. This review emphasizes the immunological changes in the lungs that occur at different phases of hypersensitivity pneumonitis and contribute to current concepts about pathogenetic mechanisms.

UR - http://www.scopus.com/inward/record.url?scp=0025942843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025942843&partnerID=8YFLogxK

M3 - Review article

VL - 169

JO - Lung

JF - Lung

SN - 0341-2040

IS - SUPPL.

ER -