Hypertension is the primary component of metabolic syndrome associated with pathologic features of kidney cancer

Neil J. Kocher, Chris Rjepaj, Haley Robyak, Erik Lehman, Jay Raman

Research output: Contribution to journalArticle

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Abstract

Purpose: To determine whether individual and/or cumulative components of metabolic syndrome (obesity, hypertension, dyslipidemia, and hyperglycemia) are associated with pathologic features of kidney cancer. Patients and methods: A review of our kidney tumor database identified 462 patients who underwent partial or radical nephrectomy for renal cell carcinoma. The NCEP ATP-III criteria were used to define metabolic syndrome (MetS). Linear fixed effects modeling and ordinal logistic regression examined the relationship between MetS (individual and cumulative components) and pathologic characteristics. Results: Two hundred and seventy-eight men and 184 women with a median age of 58 years, BMI of 31 kg/m2, tumor size of 3.7 cm, and nephrometry score of 6 were included. Ninety-seven (21 %) patients met NCEP ATP-III criteria for MetS. Hypertension was the only individual component of MetS associated with pathologic features of kidney cancer including increased tumor size [geometric mean ratio 1.17 (1.05–1.32), P = 0.03], higher tumor grade [OR 1.49 (1.03–2.17), P = 0.04], increasing nephrometry score [OR 1.77 (1.28–2.48), P = 0.001], and non-clear cell histology [OR 1.42 (1.01–2.02), P = 0.05]. Furthermore, combinations of MetS components were associated with increased tumor grade (P = 0.02), tumor stage (P = 0.02), nephrometry score (P ≤ 0.001), and non-clear cell histology (P = 0.02), only when hypertension was included. Conclusion: MetS is composed of four risk factors each implicated in carcinogenesis. We identified hypertension as the primary component associated with specific pathologic features of kidney cancer. Further studies are necessary to elucidate whether the effect of hypertension is a function of severity and/or chronicity.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalWorld Journal of Urology
Volume35
Issue number1
DOIs
StatePublished - Jan 1 2017

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Kidney Neoplasms
Hypertension
Neoplasms
Histology
Adenosine Triphosphate
Dyslipidemias
Nephrectomy
Renal Cell Carcinoma
Hyperglycemia
Carcinogenesis
Obesity
Logistic Models
Databases
Kidney

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Kocher, Neil J. ; Rjepaj, Chris ; Robyak, Haley ; Lehman, Erik ; Raman, Jay. / Hypertension is the primary component of metabolic syndrome associated with pathologic features of kidney cancer. In: World Journal of Urology. 2017 ; Vol. 35, No. 1. pp. 67-72.
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abstract = "Purpose: To determine whether individual and/or cumulative components of metabolic syndrome (obesity, hypertension, dyslipidemia, and hyperglycemia) are associated with pathologic features of kidney cancer. Patients and methods: A review of our kidney tumor database identified 462 patients who underwent partial or radical nephrectomy for renal cell carcinoma. The NCEP ATP-III criteria were used to define metabolic syndrome (MetS). Linear fixed effects modeling and ordinal logistic regression examined the relationship between MetS (individual and cumulative components) and pathologic characteristics. Results: Two hundred and seventy-eight men and 184 women with a median age of 58 years, BMI of 31 kg/m2, tumor size of 3.7 cm, and nephrometry score of 6 were included. Ninety-seven (21 {\%}) patients met NCEP ATP-III criteria for MetS. Hypertension was the only individual component of MetS associated with pathologic features of kidney cancer including increased tumor size [geometric mean ratio 1.17 (1.05–1.32), P = 0.03], higher tumor grade [OR 1.49 (1.03–2.17), P = 0.04], increasing nephrometry score [OR 1.77 (1.28–2.48), P = 0.001], and non-clear cell histology [OR 1.42 (1.01–2.02), P = 0.05]. Furthermore, combinations of MetS components were associated with increased tumor grade (P = 0.02), tumor stage (P = 0.02), nephrometry score (P ≤ 0.001), and non-clear cell histology (P = 0.02), only when hypertension was included. Conclusion: MetS is composed of four risk factors each implicated in carcinogenesis. We identified hypertension as the primary component associated with specific pathologic features of kidney cancer. Further studies are necessary to elucidate whether the effect of hypertension is a function of severity and/or chronicity.",
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Hypertension is the primary component of metabolic syndrome associated with pathologic features of kidney cancer. / Kocher, Neil J.; Rjepaj, Chris; Robyak, Haley; Lehman, Erik; Raman, Jay.

In: World Journal of Urology, Vol. 35, No. 1, 01.01.2017, p. 67-72.

Research output: Contribution to journalArticle

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AB - Purpose: To determine whether individual and/or cumulative components of metabolic syndrome (obesity, hypertension, dyslipidemia, and hyperglycemia) are associated with pathologic features of kidney cancer. Patients and methods: A review of our kidney tumor database identified 462 patients who underwent partial or radical nephrectomy for renal cell carcinoma. The NCEP ATP-III criteria were used to define metabolic syndrome (MetS). Linear fixed effects modeling and ordinal logistic regression examined the relationship between MetS (individual and cumulative components) and pathologic characteristics. Results: Two hundred and seventy-eight men and 184 women with a median age of 58 years, BMI of 31 kg/m2, tumor size of 3.7 cm, and nephrometry score of 6 were included. Ninety-seven (21 %) patients met NCEP ATP-III criteria for MetS. Hypertension was the only individual component of MetS associated with pathologic features of kidney cancer including increased tumor size [geometric mean ratio 1.17 (1.05–1.32), P = 0.03], higher tumor grade [OR 1.49 (1.03–2.17), P = 0.04], increasing nephrometry score [OR 1.77 (1.28–2.48), P = 0.001], and non-clear cell histology [OR 1.42 (1.01–2.02), P = 0.05]. Furthermore, combinations of MetS components were associated with increased tumor grade (P = 0.02), tumor stage (P = 0.02), nephrometry score (P ≤ 0.001), and non-clear cell histology (P = 0.02), only when hypertension was included. Conclusion: MetS is composed of four risk factors each implicated in carcinogenesis. We identified hypertension as the primary component associated with specific pathologic features of kidney cancer. Further studies are necessary to elucidate whether the effect of hypertension is a function of severity and/or chronicity.

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