Hypnotic effectiveness of sodium salicylamide with short-term use: Sleep laboratory studies

Costas R. Soldatos, Anthony Kales, Edward O. Bixler, Martin B. Scharf, Joyce D. Kales

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Sodium salicylamide in doses of 650 and 1,300 mg was evaluated in two separate sleep laboratory drug evaluation studies of insomniac patients. Each study utilized a standard protocol of 10 consecutive laboratory nights consisting of four placebo nights for adaptation and baseline, three drug nights for short-term drug administration and three placebo nights for evaluating withdrawal. Neither dose had a clear-cut hypnotic effect in inducing or maintaining sleep. Sleep stages were not affected by drug administration or drug withdrawal. Both the objective findings and subjective estimates suggest that the 1,300-mg dose may have a slight sedative effect. However, when salicylamide is used as an ingredient in over-the-counter preparations, the usual dose is only 200-400 mg.

Original languageEnglish (US)
Pages (from-to)193-198
Number of pages6
JournalPharmacology
Volume16
Issue number4
DOIs
StatePublished - Jan 1 1978

All Science Journal Classification (ASJC) codes

  • Pharmacology

Fingerprint Dive into the research topics of 'Hypnotic effectiveness of sodium salicylamide with short-term use: Sleep laboratory studies'. Together they form a unique fingerprint.

Cite this