Hypocholesterolemic Agent Compactin (ML-236B). Total Synthesis of the Hexahydronaphthalene Portion

Raymond L. Funk, Wayne E. Zeller

Research output: Contribution to journalLetter

80 Scopus citations

Abstract

A synthesis of 2, the hexahydronaphthalene portion of the hypocholesterolemic agent compactin (1), is described. The four contiguous asymmetric centers of 1 were established in an efficient stereospecific manner via a Lewis acid mediated intramolecular Diels-Alder reaction of 11.

Original languageEnglish (US)
Pages (from-to)180-182
Number of pages3
JournalJournal of Organic Chemistry
Volume47
Issue number1
DOIs
StatePublished - Jan 1 1982

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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