Hypocholesterolemic agent compactin (ML-236B). Total synthesis of the hexahydronaphthalene portion

Raymond Lee Funk, Wayne E. Zeller

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

A synthesis of 2, the hexahydronaphthalene portion of the hypocholesterolemic agent compactin (1), is described. The four contiguous asymmetric centers of 1 were established in an efficient stereospecific manner via a Lewis acid mediated intramolecular Diels-Alder reaction of 11.

Original languageEnglish (US)
Pages (from-to)180-182
Number of pages3
JournalJournal of Organic Chemistry
Volume47
Issue number1
StatePublished - 1982

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Lewis Acids
mevastatin

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

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abstract = "A synthesis of 2, the hexahydronaphthalene portion of the hypocholesterolemic agent compactin (1), is described. The four contiguous asymmetric centers of 1 were established in an efficient stereospecific manner via a Lewis acid mediated intramolecular Diels-Alder reaction of 11.",
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Hypocholesterolemic agent compactin (ML-236B). Total synthesis of the hexahydronaphthalene portion. / Funk, Raymond Lee; Zeller, Wayne E.

In: Journal of Organic Chemistry, Vol. 47, No. 1, 1982, p. 180-182.

Research output: Contribution to journalArticle

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