Abstract
Aphasia is a language disorder affecting more than one million people in the US. While language function has traditionally been the focus of neuroimaging research, other cognitive functions are affected in this population, which has implications not only for those specific processes but also for the interaction of language and other cognitive functions. Resting state fMRI (rs-fMRI) is a practical and informative way to explore and characterize general cognitive engagement and/or health in this population, but it is currently underutilized. The aim of this study was to explore the functional connectivity in resting state networks (RSNs) and in the semantic network in seven persons with aphasia (PWA) who were at least 6 months post onset compared with 11 neurologically healthy adults (NHA) in order to gain a more comprehensive understanding of general cognitive engagement in aphasia. These preliminary results show that PWA exhibit hypoconnectivity in the semantic network and all RSNs except the visual network. Compared with NHA, PWA appear to have fewer cross- and left-hemispheric connections. However, PWA exhibit some stronger connections than NHA within the semantic network, which could indicate compensatory mechanisms. Importantly, connectivity for RSNs appear to increase with decreasing aphasia severity and decrease with increasing lesion size. This knowledge has the potential to improve aphasia therapy by furthering the understanding of lesion effects on the cognitive system as a whole, which can guide treatment target selection and promotion of favorable neural reorganization for optimal recovery of function.
| Original language | English (US) |
|---|---|
| Article number | 91 |
| Journal | Frontiers in Human Neuroscience |
| Volume | 11 |
| DOIs | |
| State | Published - Feb 28 2017 |
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All Science Journal Classification (ASJC) codes
- Neuropsychology and Physiological Psychology
- Neurology
- Psychiatry and Mental health
- Biological Psychiatry
- Behavioral Neuroscience
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Hypoconnectivity of resting-state networks in persons with aphasia compared with healthy age-matched adults. / Sandberg, Chaleece W.
In: Frontiers in Human Neuroscience, Vol. 11, 91, 28.02.2017.Research output: Contribution to journal › Article
TY - JOUR
T1 - Hypoconnectivity of resting-state networks in persons with aphasia compared with healthy age-matched adults
AU - Sandberg, Chaleece W.
PY - 2017/2/28
Y1 - 2017/2/28
N2 - Aphasia is a language disorder affecting more than one million people in the US. While language function has traditionally been the focus of neuroimaging research, other cognitive functions are affected in this population, which has implications not only for those specific processes but also for the interaction of language and other cognitive functions. Resting state fMRI (rs-fMRI) is a practical and informative way to explore and characterize general cognitive engagement and/or health in this population, but it is currently underutilized. The aim of this study was to explore the functional connectivity in resting state networks (RSNs) and in the semantic network in seven persons with aphasia (PWA) who were at least 6 months post onset compared with 11 neurologically healthy adults (NHA) in order to gain a more comprehensive understanding of general cognitive engagement in aphasia. These preliminary results show that PWA exhibit hypoconnectivity in the semantic network and all RSNs except the visual network. Compared with NHA, PWA appear to have fewer cross- and left-hemispheric connections. However, PWA exhibit some stronger connections than NHA within the semantic network, which could indicate compensatory mechanisms. Importantly, connectivity for RSNs appear to increase with decreasing aphasia severity and decrease with increasing lesion size. This knowledge has the potential to improve aphasia therapy by furthering the understanding of lesion effects on the cognitive system as a whole, which can guide treatment target selection and promotion of favorable neural reorganization for optimal recovery of function.
AB - Aphasia is a language disorder affecting more than one million people in the US. While language function has traditionally been the focus of neuroimaging research, other cognitive functions are affected in this population, which has implications not only for those specific processes but also for the interaction of language and other cognitive functions. Resting state fMRI (rs-fMRI) is a practical and informative way to explore and characterize general cognitive engagement and/or health in this population, but it is currently underutilized. The aim of this study was to explore the functional connectivity in resting state networks (RSNs) and in the semantic network in seven persons with aphasia (PWA) who were at least 6 months post onset compared with 11 neurologically healthy adults (NHA) in order to gain a more comprehensive understanding of general cognitive engagement in aphasia. These preliminary results show that PWA exhibit hypoconnectivity in the semantic network and all RSNs except the visual network. Compared with NHA, PWA appear to have fewer cross- and left-hemispheric connections. However, PWA exhibit some stronger connections than NHA within the semantic network, which could indicate compensatory mechanisms. Importantly, connectivity for RSNs appear to increase with decreasing aphasia severity and decrease with increasing lesion size. This knowledge has the potential to improve aphasia therapy by furthering the understanding of lesion effects on the cognitive system as a whole, which can guide treatment target selection and promotion of favorable neural reorganization for optimal recovery of function.
UR - http://www.scopus.com/inward/record.url?scp=85016050078&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85016050078&partnerID=8YFLogxK
U2 - 10.3389/fnhum.2017.00091
DO - 10.3389/fnhum.2017.00091
M3 - Article
C2 - 28293185
AN - SCOPUS:85016050078
VL - 11
JO - Frontiers in Human Neuroscience
JF - Frontiers in Human Neuroscience
SN - 1662-5161
M1 - 91
ER -