TY - JOUR
T1 - Hypomagnesemia and incidence of osteoradionecrosis in patients with head and neck cancers
AU - Liu, Wenli
AU - Qdaisat, Aiham
AU - Zhou, Shouhao
AU - Fuller, Clifton D.
AU - Ferrarotto, Renata
AU - Guo, Ming
AU - Lai, Stephen Y.
AU - Cardoso, Richard
AU - Mohamed, Abdallah S.R.
AU - Lopez, Gabriel
AU - Narayanan, Santhosshi
AU - van Dijk, Lisanne V.
AU - Cohen, Lorenzo
AU - Bruera, Eduardo
AU - Yeung, Sai Ching J.
AU - Hanna, Ehab Y.
N1 - Funding Information:
The authors thank Erica Goodoff, ELS, for editorial support. Stephen Y. Lai, Clifton D. Fuller, and Abdallah S. R. Mohamed received funding support from the National Institutes of Health (NIH) (1R01DE025248‐01) and National Institute for Dental and Craniofacial Research (R56DE025248‐01). The University of Texas M. D. Anderson Cancer Center is supported in part by the National Institutes of Health through Cancer Center Support Grant (P30 CA016672).
Publisher Copyright:
© 2020 Wiley Periodicals LLC
PY - 2021/2
Y1 - 2021/2
N2 - Background: We aimed to determine whether hypomagnesemia predicts osteoradionecrosis development in patients with squamous cell carcinoma of the oropharynx and oral cavity who received platinum-based concurrent chemoradiation with or without induction therapy. Methods: We reviewed data from patients with head and neck cancers who had undergone chemoradiation with weekly cisplatin/carboplatin between January 1, 2010 and December 31, 2014 at our institution. Pathologic features, laboratory test results, disease stage, and social histories were recorded. The association between hypomagnesemia and osteoradionecrosis was analyzed controlling for known confounding factors. Results: Hypomagnesemia during cancer treatment was associated with osteoradionecrosis development (HR = 2.72, P =.037) independent of total radiation dose (HR = 1.07, P =.260) and smoking history (HR = 2.05, P =.056) among the patients who received platinum-based induction chemotherapy followed by concurrent chemoradiation. Conclusions: Hypomagnesemia was predictive of the development of osteoradionecrosis in patients with cancers of the oropharynx and oral cavity receiving platinum-based induction followed by concurrent chemoradiation.
AB - Background: We aimed to determine whether hypomagnesemia predicts osteoradionecrosis development in patients with squamous cell carcinoma of the oropharynx and oral cavity who received platinum-based concurrent chemoradiation with or without induction therapy. Methods: We reviewed data from patients with head and neck cancers who had undergone chemoradiation with weekly cisplatin/carboplatin between January 1, 2010 and December 31, 2014 at our institution. Pathologic features, laboratory test results, disease stage, and social histories were recorded. The association between hypomagnesemia and osteoradionecrosis was analyzed controlling for known confounding factors. Results: Hypomagnesemia during cancer treatment was associated with osteoradionecrosis development (HR = 2.72, P =.037) independent of total radiation dose (HR = 1.07, P =.260) and smoking history (HR = 2.05, P =.056) among the patients who received platinum-based induction chemotherapy followed by concurrent chemoradiation. Conclusions: Hypomagnesemia was predictive of the development of osteoradionecrosis in patients with cancers of the oropharynx and oral cavity receiving platinum-based induction followed by concurrent chemoradiation.
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U2 - 10.1002/hed.26510
DO - 10.1002/hed.26510
M3 - Article
C2 - 33094893
AN - SCOPUS:85093499177
VL - 43
SP - 613
EP - 621
JO - Head and Neck Surgery
JF - Head and Neck Surgery
SN - 1043-3074
IS - 2
ER -
