Hypomagnesemia and incidence of osteoradionecrosis in patients with head and neck cancers

Wenli Liu; Aiham Qdaisat; Shouhao Zhou; Clifton D. Fuller; Renata Ferrarotto; Ming Guo; Stephen Y. Lai; Richard Cardoso; Abdallah S.R. Mohamed; Gabriel Lopez; Santhosshi Narayanan; Lisanne V. van Dijk; Lorenzo Cohen; Eduardo Bruera; Sai Ching J. Yeung; Ehab Y. Hanna

doi:10.1002/hed.26510

Hypomagnesemia and incidence of osteoradionecrosis in patients with head and neck cancers

Wenli Liu, Aiham Qdaisat, Shouhao Zhou, Clifton D. Fuller, Renata Ferrarotto, Ming Guo, Stephen Y. Lai, Richard Cardoso, Abdallah S.R. Mohamed, Gabriel Lopez, Santhosshi Narayanan, Lisanne V. van Dijk, Lorenzo Cohen, Eduardo Bruera, Sai Ching J. Yeung, Ehab Y. Hanna

Research output: Contribution to journal › Article › peer-review

Abstract

Background: We aimed to determine whether hypomagnesemia predicts osteoradionecrosis development in patients with squamous cell carcinoma of the oropharynx and oral cavity who received platinum-based concurrent chemoradiation with or without induction therapy. Methods: We reviewed data from patients with head and neck cancers who had undergone chemoradiation with weekly cisplatin/carboplatin between January 1, 2010 and December 31, 2014 at our institution. Pathologic features, laboratory test results, disease stage, and social histories were recorded. The association between hypomagnesemia and osteoradionecrosis was analyzed controlling for known confounding factors. Results: Hypomagnesemia during cancer treatment was associated with osteoradionecrosis development (HR = 2.72, P =.037) independent of total radiation dose (HR = 1.07, P =.260) and smoking history (HR = 2.05, P =.056) among the patients who received platinum-based induction chemotherapy followed by concurrent chemoradiation. Conclusions: Hypomagnesemia was predictive of the development of osteoradionecrosis in patients with cancers of the oropharynx and oral cavity receiving platinum-based induction followed by concurrent chemoradiation.

Original language	English (US)
Pages (from-to)	613-621
Number of pages	9
Journal	Head and Neck
Volume	43
Issue number	2
DOIs	https://doi.org/10.1002/hed.26510
State	Accepted/In press - 2020

All Science Journal Classification (ASJC) codes

Otorhinolaryngology

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10.1002/hed.26510

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Liu, W., Qdaisat, A., Zhou, S., Fuller, C. D., Ferrarotto, R., Guo, M., Lai, S. Y., Cardoso, R., Mohamed, A. S. R., Lopez, G., Narayanan, S., van Dijk, L. V., Cohen, L., Bruera, E., Yeung, S. C. J., & Hanna, E. Y. (Accepted/In press). Hypomagnesemia and incidence of osteoradionecrosis in patients with head and neck cancers. Head and Neck, 43(2), 613-621. https://doi.org/10.1002/hed.26510

Liu, Wenli ; Qdaisat, Aiham ; Zhou, Shouhao ; Fuller, Clifton D. ; Ferrarotto, Renata ; Guo, Ming ; Lai, Stephen Y. ; Cardoso, Richard ; Mohamed, Abdallah S.R. ; Lopez, Gabriel ; Narayanan, Santhosshi ; van Dijk, Lisanne V. ; Cohen, Lorenzo ; Bruera, Eduardo ; Yeung, Sai Ching J. ; Hanna, Ehab Y. / Hypomagnesemia and incidence of osteoradionecrosis in patients with head and neck cancers. In: Head and Neck. 2021 ; Vol. 43, No. 2. pp. 613-621.

@article{9edb47a5f08541f1bef350cf0859c76c,

title = "Hypomagnesemia and incidence of osteoradionecrosis in patients with head and neck cancers",

abstract = "Background: We aimed to determine whether hypomagnesemia predicts osteoradionecrosis development in patients with squamous cell carcinoma of the oropharynx and oral cavity who received platinum-based concurrent chemoradiation with or without induction therapy. Methods: We reviewed data from patients with head and neck cancers who had undergone chemoradiation with weekly cisplatin/carboplatin between January 1, 2010 and December 31, 2014 at our institution. Pathologic features, laboratory test results, disease stage, and social histories were recorded. The association between hypomagnesemia and osteoradionecrosis was analyzed controlling for known confounding factors. Results: Hypomagnesemia during cancer treatment was associated with osteoradionecrosis development (HR = 2.72, P =.037) independent of total radiation dose (HR = 1.07, P =.260) and smoking history (HR = 2.05, P =.056) among the patients who received platinum-based induction chemotherapy followed by concurrent chemoradiation. Conclusions: Hypomagnesemia was predictive of the development of osteoradionecrosis in patients with cancers of the oropharynx and oral cavity receiving platinum-based induction followed by concurrent chemoradiation.",

author = "Wenli Liu and Aiham Qdaisat and Shouhao Zhou and Fuller, {Clifton D.} and Renata Ferrarotto and Ming Guo and Lai, {Stephen Y.} and Richard Cardoso and Mohamed, {Abdallah S.R.} and Gabriel Lopez and Santhosshi Narayanan and {van Dijk}, {Lisanne V.} and Lorenzo Cohen and Eduardo Bruera and Yeung, {Sai Ching J.} and Hanna, {Ehab Y.}",

note = "Funding Information: The authors thank Erica Goodoff, ELS, for editorial support. Stephen Y. Lai, Clifton D. Fuller, and Abdallah S. R. Mohamed received funding support from the National Institutes of Health (NIH) (1R01DE025248‐01) and National Institute for Dental and Craniofacial Research (R56DE025248‐01). The University of Texas M. D. Anderson Cancer Center is supported in part by the National Institutes of Health through Cancer Center Support Grant (P30 CA016672).",

year = "2020",

doi = "10.1002/hed.26510",

language = "English (US)",

volume = "43",

pages = "613--621",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley and Sons Inc.",

number = "2",

}

Hypomagnesemia and incidence of osteoradionecrosis in patients with head and neck cancers. / Liu, Wenli; Qdaisat, Aiham; Zhou, Shouhao; Fuller, Clifton D.; Ferrarotto, Renata; Guo, Ming; Lai, Stephen Y.; Cardoso, Richard; Mohamed, Abdallah S.R.; Lopez, Gabriel; Narayanan, Santhosshi; van Dijk, Lisanne V.; Cohen, Lorenzo; Bruera, Eduardo; Yeung, Sai Ching J.; Hanna, Ehab Y.

In: Head and Neck, Vol. 43, No. 2, 02.2021, p. 613-621.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Hypomagnesemia and incidence of osteoradionecrosis in patients with head and neck cancers

AU - Liu, Wenli

AU - Qdaisat, Aiham

AU - Zhou, Shouhao

AU - Fuller, Clifton D.

AU - Ferrarotto, Renata

AU - Guo, Ming

AU - Lai, Stephen Y.

AU - Cardoso, Richard

AU - Mohamed, Abdallah S.R.

AU - Lopez, Gabriel

AU - Narayanan, Santhosshi

AU - van Dijk, Lisanne V.

AU - Cohen, Lorenzo

AU - Bruera, Eduardo

AU - Yeung, Sai Ching J.

AU - Hanna, Ehab Y.

N1 - Funding Information: The authors thank Erica Goodoff, ELS, for editorial support. Stephen Y. Lai, Clifton D. Fuller, and Abdallah S. R. Mohamed received funding support from the National Institutes of Health (NIH) (1R01DE025248‐01) and National Institute for Dental and Craniofacial Research (R56DE025248‐01). The University of Texas M. D. Anderson Cancer Center is supported in part by the National Institutes of Health through Cancer Center Support Grant (P30 CA016672).

PY - 2020

Y1 - 2020

N2 - Background: We aimed to determine whether hypomagnesemia predicts osteoradionecrosis development in patients with squamous cell carcinoma of the oropharynx and oral cavity who received platinum-based concurrent chemoradiation with or without induction therapy. Methods: We reviewed data from patients with head and neck cancers who had undergone chemoradiation with weekly cisplatin/carboplatin between January 1, 2010 and December 31, 2014 at our institution. Pathologic features, laboratory test results, disease stage, and social histories were recorded. The association between hypomagnesemia and osteoradionecrosis was analyzed controlling for known confounding factors. Results: Hypomagnesemia during cancer treatment was associated with osteoradionecrosis development (HR = 2.72, P =.037) independent of total radiation dose (HR = 1.07, P =.260) and smoking history (HR = 2.05, P =.056) among the patients who received platinum-based induction chemotherapy followed by concurrent chemoradiation. Conclusions: Hypomagnesemia was predictive of the development of osteoradionecrosis in patients with cancers of the oropharynx and oral cavity receiving platinum-based induction followed by concurrent chemoradiation.

AB - Background: We aimed to determine whether hypomagnesemia predicts osteoradionecrosis development in patients with squamous cell carcinoma of the oropharynx and oral cavity who received platinum-based concurrent chemoradiation with or without induction therapy. Methods: We reviewed data from patients with head and neck cancers who had undergone chemoradiation with weekly cisplatin/carboplatin between January 1, 2010 and December 31, 2014 at our institution. Pathologic features, laboratory test results, disease stage, and social histories were recorded. The association between hypomagnesemia and osteoradionecrosis was analyzed controlling for known confounding factors. Results: Hypomagnesemia during cancer treatment was associated with osteoradionecrosis development (HR = 2.72, P =.037) independent of total radiation dose (HR = 1.07, P =.260) and smoking history (HR = 2.05, P =.056) among the patients who received platinum-based induction chemotherapy followed by concurrent chemoradiation. Conclusions: Hypomagnesemia was predictive of the development of osteoradionecrosis in patients with cancers of the oropharynx and oral cavity receiving platinum-based induction followed by concurrent chemoradiation.

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