Hypothalamic and gastric myoelectrical responses during vection-induced nausea in healthy Chinese subjects

Hua Xu Li Hua Xu, K. L. Koch, J. Summy-Long, R. M. Stern, J. F. Seaton, T. S. Harrison, Laurence Demers, S. Bingaman

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The physiology of nausea, a uniquely human symptom, is poorly understood. The purpose of this study was to measure the temporal sequences of neurohormonal responses and gastric myoelectrical activity in healthy subjects during the rotation of an optokinetic drum that produced nausea and other symptoms of motion sickness. Plasma catecholamines, vasopressin, and cortisol were measured at baseline, during minutes 1-5, 6-10, and 11-15 of drum rotation, and after rotation stopped. Electrogastrograms were recorded throughout the study. Twelve subjects (80%) developed nausea and 4-9 cycles/min of gastric tachyarrhythmias; three subjects had no nausea and no gastric dysrhythmias. Tachyarrhythmias began 3.4 ± 0.8 min after the onset of drum rotation, and nausea was reported, on average, 3 min later. During minutes 6-10 of drum rotation, vasopressin levels significantly increased in the subjects with nausea compared with subjects without nausea (P < 0.04). In the subjects with nausea, epinephrine and vasopressin increased significantly (P < 0.05) compared with baseline during minutes 6-10 and 11-15 of drum rotation. As nausea resolved during recovery, vasopressin decreased by 74%, whereas epinephrine increased 13%. We conclude that 1) in nauseated subjects, endogenous vasopressinergic and sympathetic circuits are activated before hypothalamic pituitary-adrenal pathways, 2) plasma vasopressin levels correlate most closely with the temporal onset and resolution of nausea, and 3) peripheral gastric dysrhythmias may have a role in activating central vasopressinergic neurons.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume265
Issue number4 28-4
StatePublished - Jan 1 1993

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Nausea
Stomach
Healthy Volunteers
Vasopressins
Tachycardia
Epinephrine
Motion Sickness
Catecholamines
Hydrocortisone
Neurons

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)

Cite this

Li Hua Xu, H. X., Koch, K. L., Summy-Long, J., Stern, R. M., Seaton, J. F., Harrison, T. S., ... Bingaman, S. (1993). Hypothalamic and gastric myoelectrical responses during vection-induced nausea in healthy Chinese subjects. American Journal of Physiology - Endocrinology and Metabolism, 265(4 28-4).
Li Hua Xu, Hua Xu ; Koch, K. L. ; Summy-Long, J. ; Stern, R. M. ; Seaton, J. F. ; Harrison, T. S. ; Demers, Laurence ; Bingaman, S. / Hypothalamic and gastric myoelectrical responses during vection-induced nausea in healthy Chinese subjects. In: American Journal of Physiology - Endocrinology and Metabolism. 1993 ; Vol. 265, No. 4 28-4.
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abstract = "The physiology of nausea, a uniquely human symptom, is poorly understood. The purpose of this study was to measure the temporal sequences of neurohormonal responses and gastric myoelectrical activity in healthy subjects during the rotation of an optokinetic drum that produced nausea and other symptoms of motion sickness. Plasma catecholamines, vasopressin, and cortisol were measured at baseline, during minutes 1-5, 6-10, and 11-15 of drum rotation, and after rotation stopped. Electrogastrograms were recorded throughout the study. Twelve subjects (80{\%}) developed nausea and 4-9 cycles/min of gastric tachyarrhythmias; three subjects had no nausea and no gastric dysrhythmias. Tachyarrhythmias began 3.4 ± 0.8 min after the onset of drum rotation, and nausea was reported, on average, 3 min later. During minutes 6-10 of drum rotation, vasopressin levels significantly increased in the subjects with nausea compared with subjects without nausea (P < 0.04). In the subjects with nausea, epinephrine and vasopressin increased significantly (P < 0.05) compared with baseline during minutes 6-10 and 11-15 of drum rotation. As nausea resolved during recovery, vasopressin decreased by 74{\%}, whereas epinephrine increased 13{\%}. We conclude that 1) in nauseated subjects, endogenous vasopressinergic and sympathetic circuits are activated before hypothalamic pituitary-adrenal pathways, 2) plasma vasopressin levels correlate most closely with the temporal onset and resolution of nausea, and 3) peripheral gastric dysrhythmias may have a role in activating central vasopressinergic neurons.",
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Li Hua Xu, HX, Koch, KL, Summy-Long, J, Stern, RM, Seaton, JF, Harrison, TS, Demers, L & Bingaman, S 1993, 'Hypothalamic and gastric myoelectrical responses during vection-induced nausea in healthy Chinese subjects', American Journal of Physiology - Endocrinology and Metabolism, vol. 265, no. 4 28-4.

Hypothalamic and gastric myoelectrical responses during vection-induced nausea in healthy Chinese subjects. / Li Hua Xu, Hua Xu; Koch, K. L.; Summy-Long, J.; Stern, R. M.; Seaton, J. F.; Harrison, T. S.; Demers, Laurence; Bingaman, S.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 265, No. 4 28-4, 01.01.1993.

Research output: Contribution to journalArticle

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T1 - Hypothalamic and gastric myoelectrical responses during vection-induced nausea in healthy Chinese subjects

AU - Li Hua Xu, Hua Xu

AU - Koch, K. L.

AU - Summy-Long, J.

AU - Stern, R. M.

AU - Seaton, J. F.

AU - Harrison, T. S.

AU - Demers, Laurence

AU - Bingaman, S.

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N2 - The physiology of nausea, a uniquely human symptom, is poorly understood. The purpose of this study was to measure the temporal sequences of neurohormonal responses and gastric myoelectrical activity in healthy subjects during the rotation of an optokinetic drum that produced nausea and other symptoms of motion sickness. Plasma catecholamines, vasopressin, and cortisol were measured at baseline, during minutes 1-5, 6-10, and 11-15 of drum rotation, and after rotation stopped. Electrogastrograms were recorded throughout the study. Twelve subjects (80%) developed nausea and 4-9 cycles/min of gastric tachyarrhythmias; three subjects had no nausea and no gastric dysrhythmias. Tachyarrhythmias began 3.4 ± 0.8 min after the onset of drum rotation, and nausea was reported, on average, 3 min later. During minutes 6-10 of drum rotation, vasopressin levels significantly increased in the subjects with nausea compared with subjects without nausea (P < 0.04). In the subjects with nausea, epinephrine and vasopressin increased significantly (P < 0.05) compared with baseline during minutes 6-10 and 11-15 of drum rotation. As nausea resolved during recovery, vasopressin decreased by 74%, whereas epinephrine increased 13%. We conclude that 1) in nauseated subjects, endogenous vasopressinergic and sympathetic circuits are activated before hypothalamic pituitary-adrenal pathways, 2) plasma vasopressin levels correlate most closely with the temporal onset and resolution of nausea, and 3) peripheral gastric dysrhythmias may have a role in activating central vasopressinergic neurons.

AB - The physiology of nausea, a uniquely human symptom, is poorly understood. The purpose of this study was to measure the temporal sequences of neurohormonal responses and gastric myoelectrical activity in healthy subjects during the rotation of an optokinetic drum that produced nausea and other symptoms of motion sickness. Plasma catecholamines, vasopressin, and cortisol were measured at baseline, during minutes 1-5, 6-10, and 11-15 of drum rotation, and after rotation stopped. Electrogastrograms were recorded throughout the study. Twelve subjects (80%) developed nausea and 4-9 cycles/min of gastric tachyarrhythmias; three subjects had no nausea and no gastric dysrhythmias. Tachyarrhythmias began 3.4 ± 0.8 min after the onset of drum rotation, and nausea was reported, on average, 3 min later. During minutes 6-10 of drum rotation, vasopressin levels significantly increased in the subjects with nausea compared with subjects without nausea (P < 0.04). In the subjects with nausea, epinephrine and vasopressin increased significantly (P < 0.05) compared with baseline during minutes 6-10 and 11-15 of drum rotation. As nausea resolved during recovery, vasopressin decreased by 74%, whereas epinephrine increased 13%. We conclude that 1) in nauseated subjects, endogenous vasopressinergic and sympathetic circuits are activated before hypothalamic pituitary-adrenal pathways, 2) plasma vasopressin levels correlate most closely with the temporal onset and resolution of nausea, and 3) peripheral gastric dysrhythmias may have a role in activating central vasopressinergic neurons.

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