Hypoxia-inducible factor-1α: a promising therapeutic target for autoimmune diseases

Shi Yang Guan, Rui Xue Leng, Jin Hui Tao, Xiang Pei Li, Dong Qing Ye, Nancy Olsen, Song Guo Zheng, Hai Feng Pan

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Introduction: Hypoxia-inducible factor-1α (HIF-1α) plays a crucial role in both innate and adaptive immunity. Emerging evidence indicates that HIF-1α is associated with the inflammation and pathologic activities of autoimmune diseases. Areas covered: Considering that the types of autoimmune diseases are complicated and various, this review aims to cover the typical kinds of autoimmune diseases, discuss the molecular mechanisms, biological functions and expression of HIF-1α in these diseases, and further explore its therapeutic potential. Expert opinion: Inflammation and hypoxia are interdependent. HIF-1α as a key regulator of hypoxia, exerts a crucial role in the balance between Th17 and Treg, and involves in the inflammation and pathologic activities of autoimmune diseases. Although there are many challenges remaining to be overcome, targeting HIF-1α could be a promising strategy for autoimmune diseases therapies.

Original languageEnglish (US)
Pages (from-to)715-723
Number of pages9
JournalExpert Opinion on Therapeutic Targets
Volume21
Issue number7
DOIs
StatePublished - Jul 3 2017

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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