Hypoxia-inducible factor-1α

a promising therapeutic target for autoimmune diseases

Shi Yang Guan, Rui Xue Leng, Jin Hui Tao, Xiang Pei Li, Dong Qing Ye, Nancy Olsen, Song Guo Zheng, Hai Feng Pan

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Introduction: Hypoxia-inducible factor-1α (HIF-1α) plays a crucial role in both innate and adaptive immunity. Emerging evidence indicates that HIF-1α is associated with the inflammation and pathologic activities of autoimmune diseases. Areas covered: Considering that the types of autoimmune diseases are complicated and various, this review aims to cover the typical kinds of autoimmune diseases, discuss the molecular mechanisms, biological functions and expression of HIF-1α in these diseases, and further explore its therapeutic potential. Expert opinion: Inflammation and hypoxia are interdependent. HIF-1α as a key regulator of hypoxia, exerts a crucial role in the balance between Th17 and Treg, and involves in the inflammation and pathologic activities of autoimmune diseases. Although there are many challenges remaining to be overcome, targeting HIF-1α could be a promising strategy for autoimmune diseases therapies.

Original languageEnglish (US)
Pages (from-to)715-723
Number of pages9
JournalExpert Opinion on Therapeutic Targets
Volume21
Issue number7
DOIs
StatePublished - Jul 3 2017

Fingerprint

Hypoxia-Inducible Factor 1
Autoimmune Diseases
Inflammation
Therapeutics
Expert Testimony
Adaptive Immunity
Innate Immunity

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Guan, Shi Yang ; Leng, Rui Xue ; Tao, Jin Hui ; Li, Xiang Pei ; Ye, Dong Qing ; Olsen, Nancy ; Zheng, Song Guo ; Pan, Hai Feng. / Hypoxia-inducible factor-1α : a promising therapeutic target for autoimmune diseases. In: Expert Opinion on Therapeutic Targets. 2017 ; Vol. 21, No. 7. pp. 715-723.
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abstract = "Introduction: Hypoxia-inducible factor-1α (HIF-1α) plays a crucial role in both innate and adaptive immunity. Emerging evidence indicates that HIF-1α is associated with the inflammation and pathologic activities of autoimmune diseases. Areas covered: Considering that the types of autoimmune diseases are complicated and various, this review aims to cover the typical kinds of autoimmune diseases, discuss the molecular mechanisms, biological functions and expression of HIF-1α in these diseases, and further explore its therapeutic potential. Expert opinion: Inflammation and hypoxia are interdependent. HIF-1α as a key regulator of hypoxia, exerts a crucial role in the balance between Th17 and Treg, and involves in the inflammation and pathologic activities of autoimmune diseases. Although there are many challenges remaining to be overcome, targeting HIF-1α could be a promising strategy for autoimmune diseases therapies.",
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Hypoxia-inducible factor-1α : a promising therapeutic target for autoimmune diseases. / Guan, Shi Yang; Leng, Rui Xue; Tao, Jin Hui; Li, Xiang Pei; Ye, Dong Qing; Olsen, Nancy; Zheng, Song Guo; Pan, Hai Feng.

In: Expert Opinion on Therapeutic Targets, Vol. 21, No. 7, 03.07.2017, p. 715-723.

Research output: Contribution to journalReview article

TY - JOUR

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T2 - a promising therapeutic target for autoimmune diseases

AU - Guan, Shi Yang

AU - Leng, Rui Xue

AU - Tao, Jin Hui

AU - Li, Xiang Pei

AU - Ye, Dong Qing

AU - Olsen, Nancy

AU - Zheng, Song Guo

AU - Pan, Hai Feng

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AB - Introduction: Hypoxia-inducible factor-1α (HIF-1α) plays a crucial role in both innate and adaptive immunity. Emerging evidence indicates that HIF-1α is associated with the inflammation and pathologic activities of autoimmune diseases. Areas covered: Considering that the types of autoimmune diseases are complicated and various, this review aims to cover the typical kinds of autoimmune diseases, discuss the molecular mechanisms, biological functions and expression of HIF-1α in these diseases, and further explore its therapeutic potential. Expert opinion: Inflammation and hypoxia are interdependent. HIF-1α as a key regulator of hypoxia, exerts a crucial role in the balance between Th17 and Treg, and involves in the inflammation and pathologic activities of autoimmune diseases. Although there are many challenges remaining to be overcome, targeting HIF-1α could be a promising strategy for autoimmune diseases therapies.

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