Ibotenic acid lesions of the parabranchial nucleus and conditioned taste aversion: Further evidence for an associative deficit in rats

Patricia Sue Grigson, Tsuyoshi Shimura, Steve Reilly, Ralph Norgren

Research output: Contribution to journalArticlepeer-review

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Abstract

Rats with extensive ibotenic acid lesions centered in the gustatory zone of the pontine parabrachial nucleus (PBN) failed to acquire a conditioned taste aversion (CTA) induced by lithium chloride (LiCl) toxicosis (Experiments 1 and 4). This deficit cannot be explained as an inability to either perceive or process gustatory information because lesioned rats that failed to acquire a CTA readily acquired a conditioned flavor preference (Experiment 2). Similarly, the CTA deficit cannot be attributed to an inability to experience or process visceral input because PBN-lesioned rats that failed to acquire a CTA successfully learned an aversion to a trigeminal stimulus, capsaicin, when paired with LiCl-induced illness (Experiment 3). This pattern of results supports the view that cell bodies within the PBN are essential for the associative processes that govern CTA learning.

Original languageEnglish (US)
Pages (from-to)160-171
Number of pages12
JournalBehavioral Neuroscience
Volume112
Issue number1
DOIs
StatePublished - 1998

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

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