ICAM gene cluster SNPs and prostate cancer risk in African Americans

Hankui Chen, Wenndy Hernandez, Mark Shriver, Chiledum A. Ahaghotu, Rick A. Kittles

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Abstract

Intercellular adhesion molecules (ICAMs) are known to be involved in various human cancers. An ICAM gene cluster lying within a 26 kb region on chromosome 19p13.2, and containing ICAM1, ICAM4, and ICAM5 has recently been identified as harboring a breast and prostate cancer susceptibility locus in two populations of European ancestry from Germany and Australia. The objective of this study was to confirm the ICAM association with prostate cancer in a sample of African American prostate cancer cases (N = 286) and controls (N = 391). Six single nucleotide polymorphisms (SNPs) within the three ICAM genes were genotyped. To control for potential population stratification an ancestry-adjusted association analysis was performed. We found that ICAM1 SNPs, -9A/C (rs5490) and K469E (rs5498) were associated with prostate cancer risk in men with a family history of prostate cancer (P = 0.008). Specifically, increased risk was observed for individuals who possessed the CC genotype of the -9 A/C variant (odds ratio = 2.5; 95% CI = 1.0-6.3) and at least one G allele of non-synonymous K469E variant (odds ratio = 1.8; 95% CI = 1.2-3.1). Strong linkage disequilibrium was observed across the ICAM region (P < 0.001). A common haplotype within the ICAM gene cluster, harboring the -9A/C variant was significantly associated with prostate cancer (P = 0.03), mainly due to men with family history (P = 0.01). Our results replicate previous findings of association of the ICAM gene cluster with prostate cancer and suggest that common genetic variation within ICAM1 and not ICAM5 may be an important risk factor for prostate cancer.

Original languageEnglish (US)
Pages (from-to)69-76
Number of pages8
JournalHuman genetics
Volume120
Issue number1
DOIs
StatePublished - Aug 1 2006

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Cell Adhesion Molecules
Multigene Family
African Americans
Single Nucleotide Polymorphism
Prostatic Neoplasms
Odds Ratio
Linkage Disequilibrium
Haplotypes
Population
Germany
Chromosomes
Alleles
Genotype
Breast Neoplasms
Genes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Chen, Hankui ; Hernandez, Wenndy ; Shriver, Mark ; Ahaghotu, Chiledum A. ; Kittles, Rick A. / ICAM gene cluster SNPs and prostate cancer risk in African Americans. In: Human genetics. 2006 ; Vol. 120, No. 1. pp. 69-76.
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abstract = "Intercellular adhesion molecules (ICAMs) are known to be involved in various human cancers. An ICAM gene cluster lying within a 26 kb region on chromosome 19p13.2, and containing ICAM1, ICAM4, and ICAM5 has recently been identified as harboring a breast and prostate cancer susceptibility locus in two populations of European ancestry from Germany and Australia. The objective of this study was to confirm the ICAM association with prostate cancer in a sample of African American prostate cancer cases (N = 286) and controls (N = 391). Six single nucleotide polymorphisms (SNPs) within the three ICAM genes were genotyped. To control for potential population stratification an ancestry-adjusted association analysis was performed. We found that ICAM1 SNPs, -9A/C (rs5490) and K469E (rs5498) were associated with prostate cancer risk in men with a family history of prostate cancer (P = 0.008). Specifically, increased risk was observed for individuals who possessed the CC genotype of the -9 A/C variant (odds ratio = 2.5; 95{\%} CI = 1.0-6.3) and at least one G allele of non-synonymous K469E variant (odds ratio = 1.8; 95{\%} CI = 1.2-3.1). Strong linkage disequilibrium was observed across the ICAM region (P < 0.001). A common haplotype within the ICAM gene cluster, harboring the -9A/C variant was significantly associated with prostate cancer (P = 0.03), mainly due to men with family history (P = 0.01). Our results replicate previous findings of association of the ICAM gene cluster with prostate cancer and suggest that common genetic variation within ICAM1 and not ICAM5 may be an important risk factor for prostate cancer.",
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Chen, H, Hernandez, W, Shriver, M, Ahaghotu, CA & Kittles, RA 2006, 'ICAM gene cluster SNPs and prostate cancer risk in African Americans', Human genetics, vol. 120, no. 1, pp. 69-76. https://doi.org/10.1007/s00439-006-0184-3

ICAM gene cluster SNPs and prostate cancer risk in African Americans. / Chen, Hankui; Hernandez, Wenndy; Shriver, Mark; Ahaghotu, Chiledum A.; Kittles, Rick A.

In: Human genetics, Vol. 120, No. 1, 01.08.2006, p. 69-76.

Research output: Contribution to journalArticle

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