Abstract
Despite being one of the first eukaryotic transcriptional regulatory elements identified, the sequence of a native TATA box and its significance remain elusive. Applying criteria associated with TATA boxes we queried several Saccharomyces genomes and arrived at the consensus TATA(A/T)A(A/T)(A/G). Approximately 20% of yeast genes contain a TATA box. Strikingly, TATA box-containing genes are associated with responses to stress, are highly regulated, and preferentially utilize SAGA rather than TFIID when compared to TATA-less promoters. Transcriptional regulation in yeast appears to be mechanistically bipolar, possibly reflecting a need to balance inducible stress-related responses with constitutive housekeeping functions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 699-709 |
| Number of pages | 11 |
| Journal | Cell |
| Volume | 116 |
| Issue number | 5 |
| DOIs | |
| State | Published - Mar 5 2004 |
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
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Cite this
Basehoar, A. D., Zanton, S. J., & Pugh, B. F. (2004). Identification and distinct regulation of yeast TATA box-containing genes. Cell, 116(5), 699-709. https://doi.org/10.1016/S0092-8674(04)00205-3