Identification and distinct regulation of yeast TATA box-containing genes

Andrew D. Basehoar, Sara J. Zanton, B. Franklin Pugh

Research output: Contribution to journalArticle

440 Scopus citations

Abstract

Despite being one of the first eukaryotic transcriptional regulatory elements identified, the sequence of a native TATA box and its significance remain elusive. Applying criteria associated with TATA boxes we queried several Saccharomyces genomes and arrived at the consensus TATA(A/T)A(A/T)(A/G). Approximately 20% of yeast genes contain a TATA box. Strikingly, TATA box-containing genes are associated with responses to stress, are highly regulated, and preferentially utilize SAGA rather than TFIID when compared to TATA-less promoters. Transcriptional regulation in yeast appears to be mechanistically bipolar, possibly reflecting a need to balance inducible stress-related responses with constitutive housekeeping functions.

Original languageEnglish (US)
Pages (from-to)699-709
Number of pages11
JournalCell
Volume116
Issue number5
DOIs
StatePublished - Mar 5 2004

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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