Identification and location of brain protein 4.1

Steven R. Goodman, Linda A. Casoria, Diane B. Coleman, Ian S. Zagon

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Protein 4.1 is a membrane skeletal protein that converts the low-affinity interaction between spectrin and act in into a high-affinity ternary complex of spectrin, protein 4.1, and actin that is essential to the structural stability of the erythrocyte. Pig brain was shown to contain an 87-kilodalton immunoreactive analog of protein 4.1 that has partial sequence homology with pig erythrocyte protein 4.1 and the same location as spectrin in the cortical cytoplasm of neuronal and glial cell types of the cerebellum.

Original languageEnglish (US)
Pages (from-to)1433-1436
Number of pages4
JournalScience
Volume224
Issue number4656
DOIs
StatePublished - 1984

All Science Journal Classification (ASJC) codes

  • General

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