Identification and location of brain protein 4.1

Steven R. Goodman, Linda A. Casoria, Diane B. Coleman, Ian Zagon

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Protein 4.1 is a membrane skeletal protein that converts the low-affinity interaction between spectrin and act in into a high-affinity ternary complex of spectrin, protein 4.1, and actin that is essential to the structural stability of the erythrocyte. Pig brain was shown to contain an 87-kilodalton immunoreactive analog of protein 4.1 that has partial sequence homology with pig erythrocyte protein 4.1 and the same location as spectrin in the cortical cytoplasm of neuronal and glial cell types of the cerebellum.

Original languageEnglish (US)
Pages (from-to)1433-1436
Number of pages4
JournalScience
Volume224
Issue number4656
DOIs
StatePublished - Jan 1 1984

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Spectrin
Brain
Ternary Complex Factors
Swine
Erythrocytes
Proteins
Sequence Homology
Neuroglia
Cerebellum
Actins
Membrane Proteins
Cytoplasm

All Science Journal Classification (ASJC) codes

  • General

Cite this

Goodman, S. R., Casoria, L. A., Coleman, D. B., & Zagon, I. (1984). Identification and location of brain protein 4.1. Science, 224(4656), 1433-1436. https://doi.org/10.1126/science.6374897
Goodman, Steven R. ; Casoria, Linda A. ; Coleman, Diane B. ; Zagon, Ian. / Identification and location of brain protein 4.1. In: Science. 1984 ; Vol. 224, No. 4656. pp. 1433-1436.
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Goodman, SR, Casoria, LA, Coleman, DB & Zagon, I 1984, 'Identification and location of brain protein 4.1', Science, vol. 224, no. 4656, pp. 1433-1436. https://doi.org/10.1126/science.6374897

Identification and location of brain protein 4.1. / Goodman, Steven R.; Casoria, Linda A.; Coleman, Diane B.; Zagon, Ian.

In: Science, Vol. 224, No. 4656, 01.01.1984, p. 1433-1436.

Research output: Contribution to journalArticle

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Goodman SR, Casoria LA, Coleman DB, Zagon I. Identification and location of brain protein 4.1. Science. 1984 Jan 1;224(4656):1433-1436. https://doi.org/10.1126/science.6374897