Identification and validation of tumor suppressor genes

Gavin Robertson, H. J.Su Huang, Webster K. Cavenee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Cancers are associated with frequent deletions of genetic material that select for the loss of genes regulating normal cellular physiology. Although several cancer suppressor genes have been identified from these areas of deletion, the identities of the vast majority remain unknown, making approaches leading to their localization, identification, and validation an important continuing endeavor. Those currently characterized cancer suppressors include regulators of aspects of the cell cycle, growth and transcriptional regulators, DNA repair enzymes, differentiation factors, cell motility elements, and regulators of signal transduction. Several inherited cancer predisposition genes have been mapped and cloned using meiotic genetic linkage mapping but less success has been achieved identifying those genes involved in non-familial cancer. The future localization, identification, and validation of these genes are likely to involve a combination of complementary position-oriented and function-driven approaches, some of which are detailed in this article.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalMolecular Cell Biology Research Communications
Volume2
Issue number1
DOIs
StatePublished - Jan 1 1999

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Tumor Suppressor Genes
Genes
DNA Repair Enzymes
Neoplasms
Genetic Linkage
Chromosome Mapping
Neoplasm Genes
Cell Movement
Signal Transduction
Cell Cycle
Growth

All Science Journal Classification (ASJC) codes

  • Molecular Biology

Cite this

Robertson, Gavin ; Huang, H. J.Su ; Cavenee, Webster K. / Identification and validation of tumor suppressor genes. In: Molecular Cell Biology Research Communications. 1999 ; Vol. 2, No. 1. pp. 1-10.
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Identification and validation of tumor suppressor genes. / Robertson, Gavin; Huang, H. J.Su; Cavenee, Webster K.

In: Molecular Cell Biology Research Communications, Vol. 2, No. 1, 01.01.1999, p. 1-10.

Research output: Contribution to journalArticle

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