Identification of a potent herbal molecule for the treatment of breast cancer

Srinivas Koduru, Srinivasan Sowmyalakshmi, Raj Kumar, Rohini Gomathinayagam, Jürgen Rohr, Chendil Damodaran

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Abstract

Background: Breast cancer (BCa)-related mortality still remains the second leading cause of cancer-related deaths worldwide. Patients with BCa have increasingly shown resistance and high toxicity to current chemotherapeutic drugs for which identification of novel targeted therapies are required. Methods: To determine the effect of PDBD on BCa cells, estrogen-receptor positive (ER+)-MCF-7 and estrogen-receptor negative (ER-)-MDA 231 cells were treated with PDBD and the cell viability, apoptotic, cell cycle, Western blot and Promoter assays were performed. Results: PDBD inhibitscell viability of ER+ and ER- BCa cells by inducing apoptosis without causing significant toxicity in normal breast epithelial cells. While dissecting the mechanism of action of PDBD on BCa, we found that PDBD inhibits Akt signaling and its downstream targets such as NF-κB activation, IAP proteins and Bcl-2 expression. On the other hand, activation of JNK/p38 MAPK-mediated pro-apoptotic signaling was observed in both ER+ and ER- BCa cells. Conclusion: These findings suggest that PDBD may have wide therapeutic application in the treatment of BCa.

Original languageEnglish (US)
Article number41
JournalBMC Cancer
Volume9
DOIs
Publication statusPublished - Jan 30 2009

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All Science Journal Classification (ASJC) codes

  • Genetics
  • Oncology
  • Cancer Research

Cite this

Koduru, S., Sowmyalakshmi, S., Kumar, R., Gomathinayagam, R., Rohr, J., & Damodaran, C. (2009). Identification of a potent herbal molecule for the treatment of breast cancer. BMC Cancer, 9, [41]. https://doi.org/10.1186/1471-2407-9-41